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Soybean Sprout Peptides Alleviate Obesity via PI3K-Akt and JAK-STAT Pathway Modulation, Gut Microbiota Regulation, and Metabolic Reprogramming

文献类型： 外文期刊

作者： Wu, Yi 1 ; Ling, Yilin 1 ; Yang, Yuqi 1 ; Long, Haoxing 1 ; Kong, Linghao 1 ; Song, Peiyang 1 ; Lu, Yujie 1 ; Zhao, Wanqiu 1 ; Wang, Wei 1 ; Zhu, Jingrong 3 ; Wang, Nan 4 ;

作者机构： 1.Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Zhejiang Prov Key Lab Chem & Biol Proc Technol Far, Hangzhou 310023, Peoples R China

2.Zhejiang Univ Sci & Technol, Zhejiang Spain Joint Lab Oil & Prot Nutr & Hlth, Hangzhou 310023, Peoples R China

3.Xinjiang Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Funct Nutr & Hlth Characterist Agr Prod De, Urumqi 830091, Peoples R China

4.Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Peoples R China

关键词： soybean sproutpeptides; obesity; PI3K-Aktpathway; JAK-STAT pathway; gut microbiota; metabolomics; functional food

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 16 期

页码：

收录情况： SCI

摘要： Obesity is a growing global health concern associated with severe metabolic disorders, necessitating the development of safer and more effective therapeutic strategies. Soybean sprout peptides (SSPs), derived from germinated soybeans, are bioactive compounds with potential antiobesity effects. This study aimed to investigate the molecular mechanisms of SSPs through an integrated approach combining network pharmacology, molecular docking, and in vivo experiments. SSP sequences were identified using UPLC-Orbitrap-MS/MS, and their bioactivity was predicted using PeptideRanker. Network pharmacology identified key SSP targets, including AKT1, SRC, STAT3, ESR1, FOS, and NFKB1, which are implicated in the PI3K-Akt and JAK-STAT pathways. Molecular docking validated strong interactions between SSPs and these targets. In vivo, SSP administration significantly reduced body weight gain, abdominal fat accumulation, and serum lipid abnormalities in high-fat-diet-induced obese mice while modulating gut microbiota composition by restoring the Firmicutes-to-Bacteroidetes ratio and reducing pathogenic taxa. Fecal metabolomics revealed that SSP alleviated oxidative stress and improved amino acid metabolism, contributing to its antiobesity effects. These findings suggest that SSP holds promise as a functional food ingredient or nutraceutical for obesity prevention and management.

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