A key virulence effector from cyst nematodes targets host autophagy to promote nematode parasitism
文献类型： 外文期刊
作者： Chen, Jiansong 1 ; Chen, Shiyan 1 ; Xu, Chunling 1 ; Yang, Huijun 5 ; Achom, Mingkee 1 ; Wang, Xiaohong 1 ;
作者机构： 1.Cornell Univ, Sch Integrat Plant Sci, Ithaca, NY 14853 USA
2.Guangdong Acad Agr Sci, Rice Res Inst, Guangzhou 510640, Peoples R China
3.Guangdong Acad Agr Sci, Guangdong Key Lab New Technol Rice Breeding, Guangzhou 510640, Peoples R China
4.South China Agr Univ, Coll Plant Protect, Dept Plant Pathol, Guangzhou 510642, Peoples R China
5.ARS, Robert W Holley Ctr Agr & Hlth, USDA, Ithaca, NY 14853 USA
关键词： ATG8 protein; ATG8-interacting motif; autophagy; effector; Globodera; Heterodera; plant immunity; plant-parasitic cyst nematode
期刊名称：NEW PHYTOLOGIST （ 影响因子：10.323； 五年影响因子：10.768 ）
ISSN： 0028-646X
年卷期：
页码：
收录情况： SCI
摘要： Autophagy, an intracellular degradation system conserved in eukaryotes, has been increasingly recognized as a key battlefield in plant-pathogen interactions. However, the role of plant autophagy in nematode parasitism is mostly unknown. We report here the identification of a novel and conserved effector, Nematode Manipulator of Autophagy System 1 (NMAS1), from plant-parasitic cyst nematodes (Heterodera and Globodera spp.). We used molecular and genetic analyses to demonstrate that NMAS1 is required for nematode parasitism. The NMAS1 effectors are potent suppressors of reactive oxygen species (ROS) induced by flg22 and cell death mediated by immune receptors in Nicotiana benthamiana, suggesting a key role of NMAS1 effectors in nematode virulence. Arabidopsis atg mutants defective in autophagy showed reduced susceptibility to nematode infection. The NMAS1 effectors contain predicted AuTophaGy-related protein 8 (ATG8)-interacting motif (AIM) sequences. In planta protein-protein interaction assays further demonstrated that NMAS1 effectors specifically interact with host plant ATG8 proteins. Interestingly, mutation in AIM2 of GrNMAS1 from the potato cyst nematode Globodera rostochiensis abolishes its interaction with potato StATG8 proteins and its activity in ROS suppression. Collectively, our results reveal for the first time that cyst nematodes employ a conserved AIM-containing virulence effector capable of targeting a key component of host autophagy to promote disease.
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