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Inhibitory effects of bee bread from Lepidotrigona flavibasis on testosterone propionate-induced benign prostatic hyperplasia in mice

文献类型： 外文期刊

作者： Wu, Jiao 1 ; Zhao, Yinan 2 ; Zhao, Shan 1 ; Gao, Jinglin 1 ; Wang, Shijie 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571101, Peoples R China

2.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China

关键词： bee bread; Lepidotrigona flavibasis; benign prostatic hyperplasia; prostate index; steroid hormones; proinflammatory cytokines

期刊名称：FOOD SCIENCE AND TECHNOLOGY RESEARCH （ 影响因子：0.7； 五年影响因子：1.1 ）

ISSN： 1344-6606

年卷期： 2024 年 30 卷 4 期

页码：

收录情况： SCI

摘要： Bee bread is a natural product rich in bee pollen which has biological properties for the treatment of benign prostatic hyperplasia (BPH). Whether bee bread from Lepidotrigona flavibasis, , a dominant stingless bee species in China, inhibits the development of BPH remains unclear. In this study, we evaluated the inhibitory effects of extracts of bee bread from L. flavibasis (BBLF) on testosterone propionate (TP)induced BPH in mice by prostate index, histopathological examination, and biochemical parameter analysis. The mice were assigned randomly to four groups with 12 mice for each group: control, TP group (12.5 mg/kg), TP + BBLF group (300 mg/kg), and TP + longbishu capsule group (450 mg/kg). When compared to TP group, TP + BBLF group exhibited significant reduction in prostate index and slightly relieved some symptoms like thickening and elongation of glandular epithelia. For steroid hormones and proinflammatory cytokines, the levels of estradiol (E2), 2 ), interleukin-1(3 (3 (IL-1(3), (3 ), and interleukin-6 (IL-6) in serum significantly decreased in TP + BBLF group compared to TP group. Our results elucidated that BBLF exhibited a significant inhibitory activity on TP-induced BPH, suggesting its potential capacity for antiproliferative and anti-inflammatory properties.

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