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DON affects the proliferation of zebrafish PAC2 fibroblasts by binding to ribosomes, reducing DNA replication, arresting the cell cycle and interfering with mitosis

文献类型： 外文期刊

作者： Duan, Huimin 1 ; Tian, Yongsheng 2 ; Li, Zhentong 2 ; Han, Aizhong 3 ;

作者机构： 1.Jining Med Univ, Lin Hes Academician Workstat New Med & Clin, Jining 272067, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Marine Fisheries, Minist Agr & Rural Affairs, Qingdao 266071, Peoples R China

3.Jining Med Univ, Coll Med Imaging & Lab, Jining 272067, Peoples R China

关键词： Deoxynivalenol; Zebrafish PAC2 fibroblast; Cell proliferation; Toxicity mechanism

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 303 卷

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is a type of mycotoxin that widely contaminates aquatic feed. Although the detrimental effects of DON on fish have been investigated, the specific impacts of DON on the proliferation of zebrafish PAC2 fibroblasts remain unclear. In this study, it was found that DON significantly suppressed the proliferation of zebrafish PAC2 fibroblasts in a dose-dependent manner. Through RNA-seq, GSEA, molecular docking and immunofluorescence analysis, we discovered that genes related to the ribosome, ECM and DNA replication were significantly down-regulated. Interestingly, we verified that DON binds to ribosomes and DON exposure could interfere with the mitosis of zebrafish embryonic fibroblasts and arrest the cell cycle. Additionally, we found that DON treatment activated autophagy-animals and mitophagy-animals signaling pathway. This study might offer valuable perspectives on the mechanisms beneath DON toxicity in zebrafish PAC2 fibroblasts.

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