您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Chronic exposure to low concentration of metamifop induces reproductive endocrine disruption and courtship behavior disorders in zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Lin, Lu 1 ; Zhao, Feng 1 ; Wu, Jingjing 1 ; Zhao, Yihao 1 ; Zhu, Junqi 1 ; Zhang, Tengfei 1 ; Tang, Huihua 1 ; Tang, Tao 3 ; Qiu, Lihong 2 ;

作者机构： 1.Guangxi Univ, Coll Agr, Natl Demonstrat Ctr Expt Plant Sci Educ, Guangxi Key Lab Agroenvironm & Agr Prod Safety, Nanning 530004, Guangxi, Peoples R China

2.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

关键词： Metamifop; Zebrafish; Reproductive endocrine disruption; Courtship behavior; Mechanism

期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：7.7； 五年影响因子：7.7 ）

ISSN： 0013-9351

年卷期： 2025 年 284 卷

页码：

收录情况： SCI

摘要： Metamifop, an aryloxyphenoxypropionate herbicide, is considered a threat to non-target organisms due to its widespread use and potential toxicity. However, there remains a significant gap in data regarding reproductive endpoints following exposure to metamifop at environmentally relevant concentrations. In this study, metamifop showed a moderate ability to bioconcentrate in zebrafish. Exposure to metamifop at environmental concentrations resulted in reduced egg production, suppression of courtship behavior, adverse effects on gonadal development and offspring development. The balance of testosterone, estradiol and vitellogenin levels was disturbed in the group treated with sublethal concentrations of metamifop. RNA-seq analysis of zebrafish gonads revealed abnormalities in the transcription of the steroid hormone biosynthesis pathway. Further results showed that genes important in the hypothalamus-pituitary-gonadal-liver (HPGL) axis involved in steroid hormone biosynthesis (era, gnrh3, fshr, hsd3b, cyp19a, hsd17b and vtg1) were significantly altered. In addition, we found potential binding effects between metamifop and the homology modeling proteins of aromatase CYP19A and estrogen receptor ER alpha. Overall, our study demonstrated the reproductive endocrine-disrupting effects of metamifop on zebrafish and preliminarily elucidated its mechanism, providing new insights into the environmental risk assessment of metamifop on aquatic organisms.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台