文献类型： 外文期刊
作者： Salman, Khan 1 ; Zhu, Hongjie 1 ; Sun, Ziqian 1 ; Li, Yilin 3 ; Wang, Lan 1 ; Wang, Rong 4 ; Guo, Zhikai 2 ; Jiao, Ruihua 1 ;
作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China
3.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China
4.Hainan Trop Ocean Univ, Hainan Acad Ocean & Fisheries Sci, Haikou 571126, Peoples R China
关键词： Fungus; Sesquiterpenoids; Drimane-type; Antibacterial; Cytotoxic; Aspergillus sp
期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：4.6； 五年影响因子：3.8 ）
ISSN： 2095-6975
年卷期： 2023 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived As-pergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one-and two-dimensional NMR spectroscopy. Drim-anenoids A-F (1-6) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. Drim-anenoids C (3), D (4) and F (6) showed antibacterial activity against five types of bacteria with different inhibition diameters. Drim-anenoid D (4) exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88 +/- 0.11 mu mol center dot L-1.
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