Thiolutin Is a Potential Fungicide for Controlling Phytophthora nicotianae and Its Mechanistic Study
文献类型： 外文期刊
作者： Xu, Gang 1 ; Huang, Xing 1 ; Liang, Yanqiong 1 ; Tan, Shibei 1 ; Chen, Helong 1 ; Xiong, Zijun 3 ; Ma, Xiang 2 ; Zhang, Shiqing 1 ; Yi, Kexian 1 ; Guo, Zhikai 3 ; Wu, Weihuai 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Hainan Key Lab Monitoring & Control Trop Agr Pests, Haikou 571101, Hainan, Peoples R China
2.Hainan Univ, Collaborat Innovat Ctr One Hlth, Sch Life & Hlth Sci, Hainan Prov Key Lab Hlth 1,Pathogenesis & Control, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Hainan, Peoples R China
4.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Hainan, Peoples R China
关键词：
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 21 期
页码：
收录情况： SCI
摘要： Phytophthora nicotianae is a destructive plant pathogen that causes significant agricultural losses, with current chemical control strategies leading to resistance and environmental concerns. This study identified thiolutin, a dithiopyrrolone antibiotic from Streptomyces luteireticuli ASG80, as a potent antifungal agent against multiple Phytophthora species. Thiolutin exhibited strong in vitro activity, with an EC50 value of 0.8266 mu g/mL, significantly reduced disease incidence and Phytophthora abundance in vivo, outperforming conventional fungicides such as metalaxyl. Transcriptomic analysis revealed significant downregulation of key genes in energy metabolism pathways, including mitochondrial function and oxidative phosphorylation, indicating impaired energy production and cellular metabolism. Microscopic and biochemical analyses further demonstrated that thiolutin disrupts cell membrane integrity, induces reactive oxygen species accumulation, and damages mitochondria, ultimately leading to energy metabolism disruption and fungal programmed cell death. These findings highlight thiolutin's potential as an environmentally friendly alternative for managing Phytophthora-induced plant diseases.
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