您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus

文献类型： 外文期刊

作者： Xie, Mujiao 1 ; Bao, Yuyuan 1 ; Xie, Xiaoyong 1 ; Ying, Ziwei 1 ; Ye, Guoling 1 ; Li, Chunhou 1 ; Guo, Qingyang 1 ; Zhang, Wanling 1 ; Luo, Zimeng 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr & Rural Affairs,Guangdong Prov Key Lab, Guangzhou 510300, Peoples R China

2.Guangdong Acad Sci, Inst Zool, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangdong Key Lab Anim Conservat & Resource Utiliz, Guangzhou 510260, Peoples R China

3.Guangdong Ctr Marine Dev Res, Guangzhou 510322, Peoples R China

4.Sanya Trop Fisheries Res Inst, Sanya 570203, Peoples R China

5.Southern Marine Sci & Engn Guangdong Lab Guangzhou, Guangzhou 511458, Peoples R China

6.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, 231 Xingangxi Rd, Guangzhou 510300, Peoples R China

关键词： Endangered species; Tachypleus tridentatus; Mercury pollution; Omics; Toxic mechanisms

期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.3； 五年影响因子：4.8 ）

ISSN： 1382-6689

年卷期： 2024 年 105 卷

页码：

收录情况： SCI

摘要： Mercury (Hg) pollution is threatening the health of endangered Tachypleus tridentatus whereas the toxic mechanism is still unclear. This study combined transcriptomic and metabolomics technology to reveal the toxic mechanisms of mercury (Hg 2+, 0.025 mg/L) exposing to T. tridentatus larvae for 15 days. Mercury induced cellular toxicity and cardiovascular dysfunction by dysregulating the genes related to endocrine system, such as polyubiquitin-A, cathepsin B, atrial natriuretic peptide, etc. Mercury induced lipid metabolic disorder with the abnormal increase of lysoPC, leukotriene D4, and prostaglandin E2. Cytochrome P450 pathway was activated to produce anti-inflammatory substances to reconstruct the homeostasis. Mercury also inhibited arginine generation, which may affect the development of T. tridentatus by disrupting the crucial signaling pathway. The mercury methylation caused enhancement of S-adenosylmethionine to meet the need of methyl donor. The mechanisms described in present study provide new insight into the risk assessment of mercury exposure to T. tridentatus.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台