您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Ameliorative Potential of Total Flavonoids Extract from Blumea balsamifera (L.) DC. on Uvb-Induced Sunburn in Mice

文献类型： 外文期刊

作者： Wang, Dan 1 ; Fan, Zuowang 2 ; Pang, Yuxin 3 ; Li, Xiaoting 1 ; Zhang, Yingbo 1 ; Yuan, Chao 1 ; Hu, Xuan 1 ; Jiang, Qian 1 ; Chen, Xiaolu 1 ; Yu, Fulai 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Hainan Prov Engn Res Ctr Blumea Balsamifera, Key Lab Biol & Cultivat Chinese Med Mat,Minist Ag, Haikou, Hainan, Peoples R China

2.Sanming Med & Polytech Vocat Coll, Sanming, Peoples R China

3.Guangdong Pharmaceut Univ, Sch Chinese Mat Med Resources, Yunfu, Peoples R China

关键词： antioxidation; anti-inflammatory; Blumea balsamifera (L) DC.; sunburn; total flavonoids extract

期刊名称：LATIN AMERICAN JOURNAL OF PHARMACY （ 影响因子：0.229； 五年影响因子：0.205 ）

ISSN： 0326-2383

年卷期： 2022 年 41 卷 6 期

页码：

收录情况： SCI

摘要： Blumea balsamifera (L.) DC. (Asteraceae) is widely used as a traditional medicine by Miao and Li Nations to promote skin trauma. This study was initiated to investigate the potential healing effects of total flavonoids extract from Blumea balsamifera (L.) DC. (TFE) on UVB-induced sunburn mice, and reveal its action mechanism. Five groups (n=20) were randomLy divided and the model groups treated with 85% ethanol (0.25 mL), the positive control group treated with Compound Mentholatum Ointment (CMO) (0.1 g), and the TFE group treated with TFE (0.25 mL, of 85% ethanol containing 25 mg TFE) for 11 consecutive days. The skin edema and erythema, scabs dropped time were observed every day for 11 days after UVB irradiation procedure. The samples were collected from different treated mice by sacrificing the animals on day 1, 2, 4, 7, and 11 after treatment. Serum levels of superoxide dismutase (SOD) and the skin tissue levels of glutathione (GSH ), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdH), were evaluated, and the tissue expressions of nuclear factor-kappa gene binding (NF-xB), interleukin-6 (IL-6) were determined along with skin histopathology. And the epidermal thicknesses were measured. Results showed that significant accelerated sunburn wound healing, the scabs dropped time shorten after treatment with TFE in the sunburn mice compared to model group and vehicle control group (p<0.05). Furthermore, the study confirmed that TFE were postulated its action mechanisms of influencing the levels of antioxidant enzymes and antioxidants and anti-inflammatory at different healing phases.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台