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Immune and physiological responses in Penaeus monodon to ammonia-N stress: a multi-omics approach

文献类型： 外文期刊

作者： Luo, Zhi 1 ; Zhou, Falin 1 ; Jiang, Song 1 ; Huang, Jianhua 1 ; Yang, Lishi 1 ; Yang, Qibin 1 ; Shi, Jianzhi 1 ; Li, Erchao 2 ; Ma, Zhenhua 1 ; Li, Yundong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Guangzhou, Peoples R China

2.East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth, Shanghai, Peoples R China

3.Sanya Trop Fisheries Res Inst, Key Lab Efficient Utilizat & Proc Marine Fishery R, Sanya, Peoples R China

4.Chinese Acad Fishery Sci, Shenzhen Base South China Sea Fisheries Res Inst, Shenzhen, Peoples R China

关键词： ammonia-N stress; transcriptome; metabolome; shrimp; immune response; oxidative stress

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：5.9； 五年影响因子：6.8 ）

ISSN： 1664-3224

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Ammonia-N stress is a significant environmental factor that adversely affects the health and productivity of aquaculture species. This study investigates the effects of ammonia-N stress on the shrimp Penaeus monodon through a combination of biochemical, histological, transcriptomic, and metabolomic analyses. Shrimp were exposed to ammonia-N stress for 12 and 96 hours, and key markers of oxidative stress, nitrogen metabolism, immune response, and overall health were assessed. The results showed that prolonged ammonia-N exposure causes significant hepatopancreatic damage, including atrophy and deformation. Transcriptomic analysis revealed significant changes in gene expression related to apoptosis, immune response, and key metabolic pathways, with particular emphasis on the disruption of innate immune signaling and defense mechanisms. Metabolomic analysis identified disruptions in nucleotide turnover, antioxidant defenses, and fundamental metabolic processes. These findings suggest that ammonia-N stress induces a multifaceted stress response in shrimp, involving oxidative stress, immune activation, and metabolic disturbances. Understanding these immune-related and metabolic mechanisms provides valuable insights into the molecular responses of crustaceans to environmental stress, laying the foundation for assessing the ecological risk of ammonia-N and identifying potential immunological biomarkers for monitoring and mitigating its adverse effects in aquaculture systems.

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