文献类型： 外文期刊
作者： Wang, Fu 1 ; Zang, Zhenyuan 1 ; Zhao, Qian 1 ; Xiaoyang, Chunxiao 1 ; Lei, Xiujuan 2 ; Wang, Yingping 2 ; Ma, Yiqiao 1 ; Cao, Rongan 3 ; Song, Xixia 4 ; Tang, Lili 4 ; Deyholos, Michael K. 5 ; Zhang, Jian 1 ;
作者机构： 1.Jilin Agr Univ, Fac Agron, Changchun 130118, Peoples R China
2.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
3.Heilongjiang Bayi Agr Univ, Coll Food Sci, Daqing 163319, Peoples R China
4.Heilongjiang Acad Agr Sci, Inst Ind Crops, Harbin 150000, Peoples R China
5.Univ British Columbia, Dept Biol, Kelowna, BC V1V 1V7, Canada
关键词： Cannabidiol (CBD); cannabinoid; biosynthesis; metabolic engineering; synthetic biology
期刊名称：ACS SYNTHETIC BIOLOGY （ 影响因子：3.7； 五年影响因子：4.2 ）
ISSN： 2161-5063
年卷期： 2024 年 13 卷 7 期
页码：
收录情况： SCI
摘要： Cannabis sativa L. is a multipurpose crop with high value for food, textiles, and other industries. Its secondary metabolites, including cannabidiol (CBD), have potential for broad application in medicine. With the CBD market expanding, traditional production may not be sufficient. Here we review the potential for the production of CBD using biotechnology. We describe the chemical and biological synthesis of cannabinoids, the associated enzymes, and the application of metabolic engineering, synthetic biology, and heterologous expression to increasing production of CBD.
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