文献类型： 外文期刊

作者： Tong, Jie ¹ ; Song, Jiangwei ³ ; Zhang, Wuchao ⁴ ; Zhai, Jingbo ⁵ ; Guan, Qingli ⁶ ; Wang, Huiqing ⁷ ; Liu, Gentao ⁸ ; Zheng, Chunfu ¹⁰ ;

作者机构： 1.Hebei Univ, Coll Life Sci, Baoding 071002, Peoples R China

2.Hebei Univ, Inst Life Sci & Green Dev, Baoding 071002, Peoples R China

3.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Live, Beijing 100089, Peoples R China

4.Hebei Agr Univ, Coll Vet Med, Baoding 071000, Peoples R China

5.Inner Mongolia Minzu Univ, Med Coll, Key Lab Zoonose Prevent & Control Univ Inner Mong, Tongliao 028000, Peoples R China

6.Chinese PLA 80th Grp Army, Affiliated Hosp, Weifang 261000, Peoples R China

7.Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu 610041, Peoples R China

8.Tongji Univ, Peoples Hosp 10, Dept Oncol, Shanghai 20000, Peoples R China

9.Tongji Univ, Sch Med, Canc Ctr, Shanghai 20000, Peoples R China

10.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada

关键词： Adaptive immunity; cGAS-STING; DNA-damage response (DDR); IFN; Innate immunity

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：6.2； 五年影响因子：7.7 ）

ISSN： 1420-682X

年卷期： 2024 年 81 卷 1 期

页码：

收录情况： SCI

摘要： When cells proliferate, stress on DNA replication or exposure to endogenous or external insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are complex signaling pathways used by multicellular organisms to prevent DNA damage. Depending on the type of broken DNA, the various pathways, Base-Excision Repair (BER), Nucleotide Excision Repair (NER), Mismatch Repair (MMR), Homologous Recombination (HR), Non-Homologous End-Joining (NHEJ), Interstrand Crosslink (ICL) repair, and other direct repair pathways, can be activated separately or in combination to repair DNA damage. To preserve homeostasis, innate and adaptive immune responses are effective defenses against endogenous mutation or invasion by external pathogens. It is interesting to note that new research keeps showing how closely DDR components and the immune system are related. DDR and immunological response are linked by immune effectors such as the cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway. These effectors act as sensors of DNA damage-caused immune response. Furthermore, DDR components themselves function in immune responses to trigger the generation of inflammatory cytokines in a cascade or even trigger programmed cell death. Defective DDR components are known to disrupt genomic stability and compromise immunological responses, aggravating immune imbalance and leading to serious diseases such as cancer and autoimmune disorders. This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.