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Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection

文献类型： 外文期刊

作者： Feng, Zhihua 1 ; Fu, Yajuan 3 ; Yang, Sheng 3 ; Zhao, Heng 3 ; Lin, Minhua 3 ; Liu, Chuancheng 3 ; Huang, Weili 3 ; He, Xinyan 3 ; Chen, Yao 3 ; Chen, Jianxin 1 ; Shen, Yangkun 3 ; Li, Zhaolong 5 ; Chen, Qi 1 ;

作者机构： 1.Fujian Normal Univ, Key Lab Optoelect Sci & Technol Med, Minist Educ, Fuzhou 350117, Fujian, Peoples R China

2.Fujian Normal Univ, Coll Photon & Elect Engn, Fuzhou 350117, Fujian, Peoples R China

3.Fujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou 350117, Fujian, Peoples R China

4.Fujian Normal Univ, Coll Life Sci, Qishan Campus, Fuzhou 350117, Fujian, Peoples R China

5.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Fujian, Peoples R China

关键词： Swine alpha-coronaviruses; Host factor; Mouse model; Antibody drug; Cross-species transmission

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：6.2； 五年影响因子：7.7 ）

ISSN： 1420-682X

年卷期： 2025 年 82 卷 1 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infection is still unclear. On the basis of our RNA-Seq data and due to the potential role of sialic acid as a coreceptor, we investigated the function of sialic acid-binding Ig-like lectin 15 (Siglec-15) to determine its role as a receptor in PEDV infection. We found that Siglec-15 enhances PEDV infection by promoting viral adsorption to host cells. Coimmunoprecipitation and immunofluorescence assays revealed that Siglec-15 binds to the S1 subunit and M protein of PEDV. PEDV infectivity was significantly reduced in Siglec-15 knockout mice. In addition, we developed a monoclonal antibody targeting Siglec-15 that can effectively inhibit PEDV infection both in vitro and in vivo. Overall, our study suggests that Siglec-15 may be a receptor for PEDV infection, which is important for related mechanistic studies and reveals a novel target for anti-PEDV therapeutic development.

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