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The Infectivity and Pathogenicity Characteristics of a Recombinant Porcine Epidemic Diarrhea Virus, CHFJFQ

文献类型： 外文期刊

作者： Feng, Zhihua 1 ; Zhao, Heng 2 ; Li, Zhaolong 5 ; Lin, Minhua 2 ; Huang, Weili 2 ; Liu, Chuancheng 2 ; Shen, Yangkun 2 ; Chen, Qi 1 ;

作者机构： 1.Fujian Normal Univ, Key Lab Optoelect Sci & Technol Med, Minist Educ, Fuzhou 350117, Peoples R China

2.Fujian Normal Univ Qishan Campus, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Fuzhou 350117, Peoples R China

3.Fujian Normal Univ Qishan Campus, Coll Life Sci, Fuzhou 350117, Peoples R China

4.Fujian Normal Univ, Coll Photon & Elect Engn, Fuzhou 350117, Peoples R China

5.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China

关键词： PEDV; origin; infection; cross-species transmission

期刊名称：VIRUSES-BASEL （ 影响因子：3.5； 五年影响因子：3.7 ）

ISSN：

年卷期： 2025 年 17 卷 3 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) presents a substantial challenge to the global swine industry. However, the origin, host range, and potential cross-species transmission of PEDV remain poorly understood. This study characterizes a novel PEDV strain, CHFJFQ, isolated from diarrheic piglets in Fuqing, Fujian, China. Through sequencing and phylogenetic analysis, we determined that CHFJFQ belongs to the GIIa subgroup and is a recombinant with CH/HNXX/2016 as the major parent and NW17 as the minor parent. Compared to CV777, CHFJFQ exhibits multiple base deletions and insertions across the 5 ' UTR, ORF1a/b, S, and ORF3 genes. Phylogenetic analysis indicates shared ancestry with bat coronaviruses, though a direct zoonotic origin remains uncertain. Interestingly, CHFJFQ demonstrated its ability to infect human and mouse cell lines in vitro and, more significantly, caused in vivo infection in both pigs and mice. The primary target organs were the intestines, lungs, and spleen, resulting in 100% mortality in suckling piglets. PEDV CHFJFQ was detected in mouse tissues, but no clinical signs were observed, indicating limited cross-species pathogenicity. Overall, these findings offer crucial insights into the epidemiology, genetics, infectivity, and pathogenicity of PEDV and provide valuable information for vaccine development.

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