文献类型： 外文期刊
作者： Zhong, Liqiao 1 ; Zhang, He 2 ; Wu, Luyin 1 ; Ru, Huijun 1 ; Wei, Nian 1 ; Yao, Fan 1 ; Ni, Zhaohui 1 ; Duan, Xinbin 1 ; Li, Yunfeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Fishery Resources & Environm Sci Expt Stn Uppermid, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China
2.Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Subtrop Water Environm & Mar, Wenzhou 325035, Peoples R China
关键词： cadmium and mercury; hypothalamus-pituitary-thyroid axis; thyroid disruption; zebrafish
期刊名称：WATER （ 影响因子：3.4； 五年影响因子：3.5 ）
ISSN：
年卷期： 2023 年 15 卷 1 期
页码：
收录情况： SCI
摘要： Cadmium (Cd2+) and mercury (Hg2+) are two kinds of non-essential heavy metals. Cd2+ and Hg2+ can cause thyroid disruption, but very few researchers have investigated the thyroid-disrupting effects of these metals on fish, specifically during their early developmental transition stage from embryos to larvae. In this study, wild-type zebrafish embryos were exposed to varying concentrations (contents) of Cd2+ (0, 10, 100, and 1000 mu g/L) and Hg2+ (0, 0.1, 1, and 10 mu g/L) for 120 h. Thereafter, the thyroid hormone contents and transcriptional changes in the genes, including thyroid stimulating hormone-beta (tsh beta), thyroglobulin (tg), sodium-iodide symporter (nis), thyroid peroxidase (tpo), transthyretin (ttr), thyroid hormone receptor-alpha and -beta (thr alpha, thr beta), types I and II iodothyronine deiodinase (dio1, dio2), and uridine diphosphate glucuronosyltransferase 1 family a, b (ugt1ab) associated with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly higher in the Cd2+ and Hg2+ groups. A significant increase in the thyroxine (T4) concentration and a decrease in the triiodothyronine (T3) concentration were observed in the Cd2+-exposed zebrafish embryos/larvae. On the other hand, the T4 and T3 concentrations were observed to be significantly increased after Hg2+ exposure. Additionally, changes were noted in the expression patterns of the HPT axis-linked genes after Cd2+ and Hg2+ exposure. Based on the results of the principal component analysis (PCA), it was concluded that Cd2+ exposure significantly affected the thyroid endocrine system at a concentration of 100 mu g/L, whereas Hg2+ exposure led to a thyroid disruption at a low concentration of 0.1 mu g/L. Thus, this study demonstrated that exposure to Cd2+ and Hg2+ metal ions induced developmental toxicity and led to thyroid disruption in zebrafish embryos/larvae.
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