文献类型： 外文期刊
作者： Cheng Xiaobei 1 ; Zhao Caili 1 ; Jin Zhiwei 1 ; Hu Jianping 1 ; Zhang Zhenzhen 3 ; Zhang Chao 1 ;
作者机构： 1.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China
2.China Pharmaceut Univ, Jiangsu Key Lab Bioact Nat Prod Res, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China
关键词： Atherosclerosis; Cardiovascular diseases; Pathogenesis; Target; Natural products
期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.887； 五年影响因子：3.273 ）
ISSN： 2095-6975
年卷期： 2022 年 20 卷 11 期
页码：
收录情况： SCI
摘要： Atherosclerosis (AS) is an invisible killer among cardiovascular diseases (CVD), which has seriously threatened the life of quality. The complex pathogenesis of AS involves multiple interrelated events and cell types, such as macrophages, endothelial cells, vascular smooth muscle cells and immune cells. Currently, the efficacy of recommended statin treatment is not satisfactory. Natural products (NPs) have attracted increasing attention with regard to their broad structural diversity and biodiversity, which makes them a promising library in the demand for lead compounds with cardiovascular protective bio-activity. NPs can preclude the development of AS by regulating lipid metabolism, ameliorating inflammation, stabilizing plaques, and remodeling the gut microbiota, which lays a foundation for the application of NPs in clinical therapeutics.
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