In vitro digestion and fermentation combined with microbiomics and metabolomics reveal the mechanism of superfine yak bone powder regulating lipid metabolism by altering human gut microbiota
文献类型： 外文期刊
作者： Zhang, Jin 1 ; Li, Xiaoqiong 1 ; Zhao, Ke 1 ; Li, Huanhuan 1 ; Liu, Jingnan 2 ; Da, Se 3 ; Ciren, Dajie 3 ; Tang, Honggang 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
2.Lingnan Normal Univ, Sch Life Sci & Technol, Zhanjiang 524048, Guangdong, Peoples R China
3.Gonyal Anim Husb Technol & Ind Co Naqu, Xizang 852014, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Food Sci, 198 Shiqiao Rd, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Yak bone; In vitro digestion; In vitro fermentation; Gut microbiota; Microbiome; Metabolome; Short-chain fatty acid; Lipid metabolite
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2023 年 410 卷
页码：
收录情况： SCI
摘要： The effects of superfine yak bone powder (YBP) on human gut microbiota (HGM) were investigated by in vitro digestion and fermentation combined with microbiomics and metabolomics. Results showed that size reduction and protein structural degradation during digestion allowed superfine YBP to release more Ca2+ than CaCO3 powders with similar particle size. Moreover, the indigestible YBP further influenced HGM and was associated with increased occurrence of beneficial bacteria such as Megasphaera spp., Megamonas spp., Acidaminococcus spp., and Prevotella spp. The altered HGM was associated with greater production of short-chain fatty acids with 4-6 carbon atoms. Furthermore, the indigestible YBP was associated with up-regulation of many lipid-related metabolites, including taurine, secondary bile acids, saturated long-chain fatty acids, and omega-3/omega-6 poly-unsaturated fatty acids, which modulated favorably lipid metabolic pathways. These findings implied the po-tential activity of superfine YBP as a food fortifier in favorably altering HGM community structure and regulating lipid metabolism.
- 相关文献
作者其他论文 更多>>
-
The Effect of Type 2 Resistant Starch and Indole-3-Propionic Acid on Ameliorating High-Fat-Diet-Induced Hepatic Steatosis and Gut Dysbiosis
作者：Yang, Min;Cai, Wanhao;Wang, Chong;Yang, Min;Cai, Wanhao;Wang, Chong;Yang, Min;Li, Xinxin;Li, Jinjun;Wang, Xin;Zhu, Liying;Li, Xiaoqiong;Yang, Min;Li, Xinxin;Li, Jinjun;Wang, Xin;Zhu, Liying;Li, Xiaoqiong;Deng, Yixuan
关键词：obesity; type 2 resistant starch; indole-3-propionic acid; high-fat diet; hepatic steatosis; gut dysbiosis
-
Microbiota responses to different brans are conserved within individuals and associated with processing parameters
作者：Xu, Xianrong;Li, Jinjun;Zhu, Liying;Li, Xiaoqiong;Yao, Zhentao;Wang, Xin;Li, Jinjun;Zhu, Liying;Li, Xiaoqiong;Zhang, Ge;Qi, Yuting;Jiang, Yuanrong;Gu, Jie
关键词：Rice bran; Wheat bran; Processing techniques; In vitro fermentation; Short-chain fatty acids; Gut microbiome
-
Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin
作者：Xie, Yvhao;Li, Xinxin;Wang, Weiwei;Xie, Yvhao;Li, Xinxin;Li, Jinjun;Wang, Xin;Zhu, Liying;Li, Xiaoqiong;Xie, Yvhao;Li, Xinxin;Li, Jinjun;Wang, Xin;Zhu, Liying;Li, Xiaoqiong;Meng, Qingshi
关键词：tryptophan metabolism; gut microbiota; type 2 diabetes mellitus; metformin; LC-MS/MS; indole-3-lactic acid; indole-3-propionic acid
-
Mechanistic Study of Novel Dipeptidyl Peptidase IV Inhibitory Peptides from Goat's Milk Based on Peptidomics and In Silico Analysis
作者：Wu, Yulong;Zhu, Ruikai;Xu, Xianrong;Wu, Yulong;Zhang, Jin;Zhu, Ruikai;Zhang, Hong;Li, Dapeng;Li, Huanhuan;Tang, Honggang;Chen, Lihong;Zhao, Ke;Zhang, Hong;Li, Dapeng;Peng, Xinyan
关键词：dipeptidyl peptidase IV; inhibitory peptide; goat milk; LC-MS/MS; virtual screening; molecular docking
-
CRISPR/Cas9-meditated gene knockout in pigs proves that LGALS12 deficiency suppresses the proliferation and differentiation of porcine adipocytes
作者：Wu, Wenjing;Yin, Yajun;Zhang, Jin;Huang, Jing;Pan, Jianzhi;Yang, Ruifei;Li, Qiuyan;Zhang, Jin
关键词：LGALS12; CRISPR/Cas9; Knockout; Pig fat
-
Polygonatum kingianum Polysaccharides Enhance the Preventive Efficacy of Heat-Inactivated Limosilactobacillus reuteri WX-94 against High-Fat-High-Sucrose-Induced Liver Injury and Gut Dysbacteriosis
作者：Liu, Tianqi;Zhou, Lanqi;Song, Wei;Wang, Peng;Shi, Lin;Liu, Yuan;Wu, Shan;Dai, Xiaoshuang;Li, Xiaoqiong
关键词：Polygonatum kingianum polysaccharides; Limosilactobacillus reuteri; liver injury; fatty acid metabolism; gut microbiota
-
Identification, characterization, and insights into the mechanism of novel dipeptidyl peptidase-IV inhibitory peptides from yak hemoglobin by in silico exploration, molecular docking, and in vitro assessment
作者：Zhang, Jin;Wu, Yulong;Tang, Honggang;Li, Huanhuan;Zhao, Ke;Wu, Yulong;Da, Se;Ciren, Dajie;Peng, Xinyan;Zhang, Jin;Tang, Honggang;Zhao, Ke
关键词：Dipeptidyl peptidase IV; Peptide; Yak hemoglobin; Molecular docking; In silico screening; In vitro assessment
