In vitro digestion and fermentation combined with microbiomics and metabolomics reveal the mechanism of superfine yak bone powder regulating lipid metabolism by altering human gut microbiota
文献类型： 外文期刊
作者： Zhang, Jin 1 ; Li, Xiaoqiong 1 ; Zhao, Ke 1 ; Li, Huanhuan 1 ; Liu, Jingnan 2 ; Da, Se 3 ; Ciren, Dajie 3 ; Tang, Honggang 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
2.Lingnan Normal Univ, Sch Life Sci & Technol, Zhanjiang 524048, Guangdong, Peoples R China
3.Gonyal Anim Husb Technol & Ind Co Naqu, Xizang 852014, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Food Sci, 198 Shiqiao Rd, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Yak bone; In vitro digestion; In vitro fermentation; Gut microbiota; Microbiome; Metabolome; Short-chain fatty acid; Lipid metabolite
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2023 年 410 卷
页码：
收录情况： SCI
摘要： The effects of superfine yak bone powder (YBP) on human gut microbiota (HGM) were investigated by in vitro digestion and fermentation combined with microbiomics and metabolomics. Results showed that size reduction and protein structural degradation during digestion allowed superfine YBP to release more Ca2+ than CaCO3 powders with similar particle size. Moreover, the indigestible YBP further influenced HGM and was associated with increased occurrence of beneficial bacteria such as Megasphaera spp., Megamonas spp., Acidaminococcus spp., and Prevotella spp. The altered HGM was associated with greater production of short-chain fatty acids with 4-6 carbon atoms. Furthermore, the indigestible YBP was associated with up-regulation of many lipid-related metabolites, including taurine, secondary bile acids, saturated long-chain fatty acids, and omega-3/omega-6 poly-unsaturated fatty acids, which modulated favorably lipid metabolic pathways. These findings implied the po-tential activity of superfine YBP as a food fortifier in favorably altering HGM community structure and regulating lipid metabolism.
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