Multi-Omics Analysis to Understand the Effects of Dietary Proanthocyanidins on Antioxidant Capacity, Muscle Nutrients, Lipid Metabolism, and Intestinal Microbiota in Cyprinus carpio
文献类型： 外文期刊
作者： Jia, Rui 1 ; Hou, Yiran 1 ; Feng, Wenrong 1 ; Nomingerel, Munkhjargal 2 ; Li, Bing 1 ; Zhu, Jian 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Integrated Rice Fish Farming Ecol, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China
2.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China
关键词： proanthocyanidins; intestinal microbiota; multi-omics; muscle nutrients; PPAR signaling pathway; Cyprinus carpio
期刊名称：ANTIOXIDANTS （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN：
年卷期： 2023 年 12 卷 12 期
页码：
收录情况： SCI
摘要： Proanthocyanidins (Pros), a natural polyphenolic compound found in grape seed and other plants, have received significant attention as additives in animal feed. However, the specific mechanism by which Pros affect fish health remains unclear. Therefore, the aim of this study was to investigate the potential effects of dietary Pro on common carp by evaluating biochemical parameters and multi-omics analysis. The results showed that Pro supplementation improved antioxidant capacity and the contents of polyunsaturated fatty acids (n-3 and n-6) and several bioactive compounds. Transcriptomic analysis demonstrated that dietary Pro caused an upregulation of the sphingolipid catabolic process and the lysosome pathway, while simultaneously downregulating intestinal cholesterol absorption and the PPAR signaling pathway in the intestines. Compared to the normal control (NC) group, the Pro group exhibited higher diversity in intestinal microbiota and an increased relative abundance of Cetobacterium and Pirellula. Furthermore, the Pro group had a lower Firmicutes/Bacteroidetes ratio and a decreased relative abundance of potentially pathogenic bacteria. Collectively, dietary Pro improved antioxidant ability, muscle nutrients, and the diversity and composition of intestinal microbiota. The regulation of lipid metabolism and improvement in muscle nutrients were linked with changes in the intestinal microbiota.
- 相关文献
作者其他论文 更多>>
-
Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinensis
作者：Jiang, Gang;Yan, Fengyuan;Xu, Yuanfeng;Li, Jianlin;Feng, Wenrong;Tang, Yongkai;Tang, Yongkai;Hua, Guo an;Li, Wen jing;Zhou, Jun
关键词：Chinese mitten crab; Hypoxic stress; Aeromonas veronii infection; Immunity; Metabolism
-
Transcriptomic profiling reveals potential regulatory genes and molecular mechanisms of residual feed intake in Jian carp (Cyprinus carpio var. Jian)
作者：Wang, Wenqian;Jiang, Kemeng;Li, Jianlin;Feng, Wenrong;Sewo, Daniel Yohannes;Tang, Yongkai;Xu, Yuanfeng;Li, Jianlin;Feng, Wenrong;Tang, Yongkai;Zhang, Zhihua
关键词：Cyprinus carpio; Feed efficiency; Residual feed intake; Transcriptome
-
Deleted in malignant brain tumors 1 (DMBT1) gene relate to immune priming and phagocytosis modulation in the small abalone Haliotis diversicolor
作者：Yao, Tuo;Tan, Junyuan;Lu, Jie;Fu, Shengli;Xie, Zhilv;Cheng, Changhong;Ye, Lingtong;Tan, Junyuan;Xie, Zhilv;Li, Bing
关键词：Abalone; DMBT1; Innate immunity; Phagocytic activity; Reinfection
-
Variability in Morphological Traits and Nutritional Profiles of Adult Eriocheir sinensis in Different Aquacultural Regions
作者：Feng, Wenrong;He, Qinghong;Li, Jianlin;Xu, Yuanfeng;Jiang, Gang;Tang, Yongkai;Zhou, Jun;Hua, Guoan;Tang, Yongkai
关键词：
Eriocheir sinensis ; aquaculture; morphometrics; amino acid; fatty acid -
Effects of starvation-refeeding on antioxidant status, metabolic function, and adaptive response in the muscle of Cyprinus carpio
作者：Feng, Wenrong;Li, Jianlin;Xu, Yuanfeng;Jiang, Gang;Su, Shengyan;Jia, Rui;Tang, Yongkai;Zhang, Zhihua
关键词：Starvation; Oxidative stress; Mitophagy; FoxO signaling pathway; Cyprinus carpio
-
Physiological response and lipid metabolism induced by re-feeding in Jian carp (Cyprinus carpio var. Jian) subjected to short-term starvation
作者：Zhang, Yu;Tang, Yongkai;Jiang, Gang;Feng, Wenrong;Xu, Yuanfeng;Li, Jianlin;Tang, Yongkai;Zhang, Zhihua
关键词：Cyprinus carpio var. Jian; Starvation and refeeding; Growth performance; Physiological response; Lipid metabolism
-
High-throughput sequencing reveals the regulatory role of microRNAs in the Chinese mitten crab (Eriocheir sinensis) response to heat stress
作者：Xu, Yuanfeng;Feng, Wenrong;Li, Jianlin;Tang, Yongkai;Xu, Yuanfeng;Feng, Wenrong;Liu, Yuxin;Li, Jianlin;Tang, Yongkai;Hua, Guoan;Zhou, Jun
关键词：MiRNA; Heat stress; TGF-beta signaling pathway;
Eriocheir sinensis
