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Integrated analysis of blood mRNAs and microRNAs reveals immune changes with age in the Yangtze finless porpoise (Neophocaena asiaeorientalis)

文献类型： 外文期刊

作者： Yin, Denghua 1 ; Lin, Danqing 2 ; Guo, Hongyi 1 ; Gu, Hailong 1 ; Ying, Congping 2 ; Zhang, Ya 1 ; Zhang, Jialu 2 ; Liu, 1 ;

作者机构： 1.Shanghai Ocean Univ, Shanghai Univ Key Lab Marine Anim Taxon & Evolut, Shanghai 201306, Peoples R China

2.CAFS, Freshwater Fisheries Res Ctr, Minist Agr & Rural Affairs, Sci Observing & Expt Stn Fishery Resources & Envi, Wuxi 214081, Jiangsu, Peoples R China

关键词： Yangtze finless porpoise; Immune changes; Aging; Blood transcriptome

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY （ 影响因子：2.231； 五年影响因子：2.215 ）

ISSN： 1096-4959

年卷期： 2021 年 256 卷

页码：

收录情况： SCI

摘要： Populations of Yangtze finless porpoises (YFPs) have rapidly declined in recent decades, raising the specter of extinction. In order to protect YFPs, a greater understanding of their biology is needed, including studying how their immune functioning changes with age. Here, we systematically studied the hematologic and biochemical parameters, as well as mRNAs and miRNAs profiles of old, adult, and young YFPs. The lymphocyte (LYMPH), neutrophils (NEUT) and eosinophils (EOS) counts in old YFPs were lower than those in young or adult YFPs. When comparing old to adult YFPs, the latter showed higher expression of genes associated with the innate and adaptive immune systems, including complement components, major histocompatibility complex, interleukins, TNF receptors, and chemokines/cytokines. When comparing old to young YFPs, the most striking difference was in higher toll-like receptor signaling in the latter. When comparing adult to young YFPs, the former exhibited higher expression of genes related to adaptive immunity and the FoxO signaling pathway, but lower expression of genes associated with the PI3K-Akt signaling pathway. Negative miRNA-mRNA interactions were predicted in comparisons of the old and adult (326), old and young (316), adult and young (211) groups. Overall, these results delineate a progression from early innate immune function dominance to adaptive immune function enhancement (young to adult) and deterioration (adult to old), and the changes in miRNAs profile correlate with the effects of age on immune functions. This study is the first to observe the changes of immune function of Yangtze finless porpoise with age using transcriptome method, and the study's findings are of great significance for protecting this endangered species.

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