The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance
文献类型： 外文期刊
作者： Umar, Zeeshan 1 ; Chen, Qiwei 1 ; Tang, Biao 1 ; Xu, Yongchang 1 ; Wang, Jinzi 7 ; Zhang, Huimin 1 ; Ji, Kai 1 ; Jia, Xu; 1 ;
作者机构： 1.Zhejiang Univ, Dept Pathogen Biol, Affiliated Hosp 2, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
2.Zhejiang Univ, Dept Gen Intens Care Unit, Affiliated Hosp 2, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
3.Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
4.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China
5.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
6.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
7.Guangxi Univ Nationalities, Sch Marine Sci & Biotechnol, Guangxi Key Lab Utilizat Microbial & Bot Resource, Nanning 530008, Guangxi, Peoples R China
8.Guangxi Univ Nationalities, Sch Marine Sci & Biotechnol, Guangxi Key Lab Polysaccharide Mat & Modificat, Nanning 530008, Guangxi, Peoples R China
9.Univ Illinois, Canc Ctr Illinois, Urbana, IL 61801 USA
10.Chengdu Med Coll, Noncoding RNA & Drug Discovery Key Lab Sichuan Pr, Chengdu 610500, Sichuan, Peoples R China
期刊名称：ENVIRONMENTAL MICROBIOLOGY （ 影响因子：5.491； 五年影响因子：6.438 ）
ISSN： 1462-2912
年卷期：
页码：
收录情况： SCI
摘要： The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmid-borne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline resistance. Natural source for an ongoing family of Tet(X) resistance determinants is poorly understood. Here, we report the discovery of 26 new variants [tet(X18) to tet(X44)] from the poultry pathogen Riemerella anatipestifer, which expands extensively the current Tet(X) family. R. anatipestifer appears as a natural reservoir for tet(X), of which the chromosome harbours varied copies of tet(X) progenitors. Despite that an inactive ancestor rarely occurs, the action and mechanism of Tet(X2/4)-P, a putative Tet(X) progenitor, was comprehensively characterized, giving an intermediate level of tigecycline resistance. The potential pattern of Tet(X) dissemination from ducks to other animals and humans was raised, in the viewpoint of ecological niches. Therefore, this finding defines a large pool of natural sources for Tet(X) tigecycline resistance, heightening the need of efficient approaches to manage the inter-species transmission of tet(X) resistance determinants.
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