Chiral Nanoclusters as Alternative Therapeutic Strategies to Confront the Health Threat from Antibiotic-Resistant Pathogens
文献类型： 外文期刊
作者： Wang, Zhe 1 ; Tian, Yijin 1 ; Hao, Jinghua 1 ; Liu, Ya 1 ; Tang, Jie 1 ; Xu, Zhenlan 4 ; Liu, Yin 1 ; Tang, Biao 5 ; Huang, Xiu 6 ; Zhu, Nali 1 ; Li, Zhigang 1 ; Hu, Ligang 2 ; Li, Lingxiangyu 1 ; Wang, Yawei 2 ; Jiang, Guibin 2 ;
作者机构： 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310024, Peoples R China
6.Sichuan Univ, West China Sch Publ Hlth, Chengdu 610064, Peoples R China
7.Sichuan Univ, West China Hosp 4, Chengdu 610065, Peoples R China
关键词： Antibacterial activity; chiral silver nanoclusters; antimicrobial resistance; cytocompatibility; Pseudomonas aeruginosa
期刊名称：ACS NANO （ 影响因子：17.1； 五年影响因子：17.1 ）
ISSN： 1936-0851
年卷期： 2024 年 18 卷 9 期
页码：
收录情况： SCI
摘要： Pseudomonas aeruginosa (P. aeruginosa), a drug-resistant Gram-negative pathogen, is listed among the "critical" group of pathogens by the World Health Organization urgently needing efficacious antibiotics in the clinics. Nanomaterials especially silver nanoparticles (AgNPs) due to the broad-spectrum antimicrobial activity are tested in antimicrobial therapeutic applications. Pathogens rapidly develop resistance to AgNPs; however, the health threat from antibiotic-resistant pathogens remains challenging. Here we present a strategy to prevent bacterial resistance to silver nanomaterials through imparting chirality to silver nanoclusters (AgNCs). Nonchiral AgNCs with high efficacy against P. aeruginosa causes heritable resistance, as indicated by a 5.4-fold increase in the minimum inhibitory concentration (MIC) after 9 repeated passages. Whole-genome sequencing identifies a Rhs mutation related to the wall of Gram-negative bacteria that possibly causes morphology changes in resistance compared to susceptible P. aeruginosa. Nevertheless, AgNCs with laevorotary chirality (l-AgNCs) induce negligible resistance even after 40 repeated passages and maintain a superior antibacterial efficiency at the MIC. l-AgNCs also show high cytocompatibility; negligible cytotoxicity to mammalian cells including JB6, H460, HEK293, and RAW264.7 is observed even at 30-fold MIC. l-AgNCs thus are examined as an alternative to levofloxacin in vivo, healing wound infections of P. aeruginosa efficaciously. This work provides a potential opportunity to confront the rising threat of antimicrobial resistance by developing chiral nanoclusters.
- 相关文献
作者其他论文 更多>>
-
A systemic study of cyenopyrafen in strawberry cultivation system: Efficacy, residue behavior, and impact on honeybees (Apis mellifera L.)
作者：Ye, Hui;Jiang, Jinhua;Lei, Yuan;Fang, Nan;Luo, Yuqin;Li, Yanjie;Wang, Xiangyun;He, Hongmei;Yu, Jianzhong;Xu, Zhenlan;Zhang, Changpeng;Cheng, Youpu;Li, Yanjie;Zhang, Changpeng
关键词：Strawberry; Cyenopyrafen; Residue; Honeybee; Gut microbiota; RNA-Seq
-
Comprehensive multi-omics investigation of sub-chronic toxicity induced by Cadmium and Triazophos Co-exposure in hook snout carps ( Opsariichthys bidens )
作者：Wang, Yanhua;Xu, Zhenlan;Lv, Lu;Wang, Dou;Wang, Xinquan;Gu, Weijie;Jin, Yuanxiang
关键词：Metabolome; Microbiology; Cadmium; Triazophos; Hook snout carp
-
Biochemical and molecular-level effects of co-exposure to chlorpyrifos and lambda-cyhalothrin on the earthworm (Eisenia fetida)
作者：Wang, Dou;Yang, Guiling;Xu, Zhenlan;Lv, Lu;Tang, Tao;Wang, Yanhua;Chen, Liping
关键词：Earthworm; Toxicological mechanism; Mixture effect; Enzymatic activity; Gene transcription
-
Detection of clinical Serratia marcescens isolates carrying bla KPC-2 in a hospital in China
作者：Tang, Biao;Yue, Min;Tang, Biao;Zhao, Haoyu;Huang, Yuting;Tang, Biao;Zhao, Haoyu;Huang, Yuting;Zhao, Haoyu;Wang, Juan;Li, Jie;Liu, Na;Yue, Min
关键词：Serratia marcescens; Antimicrobial resistance; Genome sequences; Human
-
Transposable elements impact the population divergence of rice blast fungus Magnaporthe oryzae
作者：Lin, Lianyu;Sun, Ting;Guo, Jiayuan;Lin, Lili;Wang, Zhe;Zhang, Dongmei;Lu, Guodong;Zheng, Huakun;Zhong, Zhenhui;Wang, Zonghua;Guo, Jiayuan;Chen, Meilian;Han, Yijuan;Wang, Zonghua;Bao, Jiandong;Norvienyeku, Justice;Rensing, Christopher;Zhong, Zhenhui
关键词：transposable element; population divergence; rice subspecies adaptation; rice blast disease
-
Uptake, accumulation and toxicity of short chain chlorinated paraffins to wheat (Triticum aestivum L.)
作者：Yu, Jianzhong;Zhao, Xueping;Tang, Tao;Zhang, Changpeng;Xu, Zhenlan;Tang, Qing;Yin, Ge;Chen, Weifang;Li, Lingxiangyu;Chen, Weifang;Lv, Jitao;Zhang, Chenghao;Ye, Yunxiang;Song, Xijiao;Zeng, Lixi
关键词：Short chain chlorinated paraffins; Root concentration factor; Translocation factor; Cellular ultrastructure; Hydrophobicity
-
Contents of flavonoid compounds in Dendrobium officinale Kimura et Migo determined by QuEChERS-HPLC-MS/MS: Method validation and influencing factors
作者：Sun, Fengting;Xu, Zhenlan;Zhu, Zuoyi;Zhang, Chunrong;Tang, Tao;Wang, Qiang;Zhao, Xueping;Sun, Fengting;Sheng, Qing;Xu, Xiaoyan;Gao, Yan;Han, Xinyu
关键词：QuEChERS; Flavonoid components; The origin; Cultivation method; Dendrobium officinale Kimura et Migo
