Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation
文献类型： 外文期刊
作者： Zhang, Meimei 1 ; Liu, Shaojuan 1 ; Wu, Zebiao 1 ; Wang, Chuanlong 1 ; Zhang, Hangchao 1 ; Yang, Jie 1 ; Guo, Chunhe 1 ; Dai, Manman 1 ; Wang, Xiaofan 1 ; Ren, Wenkai 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangzhou 510642, Peoples R China
2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
3.Sichuan Agr Univ, Key Lab Sichuan Prov, Anim Dis Resistant Nutr, Chengdu 611130, Peoples R China
关键词： ACOT11; macrophage; fatty acid; IFNGR2; palmitoylation
期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：9.5； 五年影响因子：8.1 ）
ISSN： 1674-7305
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Fatty acid metabolism mediates macrophage function; however, the underlying mechanism by which fatty acid metabolism regulates macrophage interleukin (IL)-1 beta production remains to be uncovered. Here, we used genome-wide association studies (GWAS) to identify several porcine serum IL-1 beta-related genes, such as the fatty acid metabolizing enzyme acyl-CoA thioesterase 11 (ACOT11). We then demonstrated that inflammatory macrophages have low expression of ACOT11, and ACOT11 overexpression inhibits IL-1 beta maturation from inflammatory macrophages. Mechanistically, ACOT11 promotes intracellular fatty acids accumulation, including eicosatetraenoic acid (EA) and stearic acid (SA), which inhibit activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling through palmitoylation of interferon (IFN)-gamma receptor (IFNGR) 2 at C261site. Furthermore, we also found that EA attenuates lipopolysaccharide (LPS)-induced sepsis in mice. Collectively, our findings reveal a mechanism involving ACOT11-mediated post-translational modification that regulates macrophage function and provide a promising therapeutic target for the treatment of inflammatory diseases associated with macrophages.
- 相关文献
作者其他论文 更多>>
-
Black Soldier Fly: A Keystone Species for the Future of Sustainable Waste Management and Nutritional Resource Development: A Review
作者：Tariq, Muhammad Raheel;Liu, Youming;Tariq, Muhammad Raheel;Liu, Shaojuan;Wang, Fei;Wang, Hui;Mo, Qianyuan;Zhuang, Zhikai;Zheng, Chaozhong;Liang, Yanwen;Ur Rehman, Kashif;Ur Rehman, Kashif;Helvaci, Murat;Qin, Jianguang;Li, Chengpeng
关键词：
Hermetia illucens ; organic waste valorization; insect bioconversion; alternative protein production; insect genomics -
Dietary Influence on Growth, Physicochemical Stability, and Antimicrobial Mechanisms of Antimicrobial Peptides in Black Soldier Fly Larvae
作者：Liu, Shaojuan;Tariq, Muhammad Raheel;Zhang, Qihui;Wang, Hui;Wang, Fei;Zheng, Chaozhong;Zhuang, Zhikai;Wang, Leiyu;Tariq, Muhammad Raheel;Zhang, Qihui;Li, Kuntai;Li, Kuntai
关键词：black soldier fly larvae; antimicrobial peptides; growth performance; physicochemical stability; transcriptomic analysis
-
Response of Asplenium nidus to Drought Stress and Roles of AVP1 Genes
作者：Liang, Jingwen;Xu, Shitao;Yang, Jie;Ye, Zihan;Cai, Zeping;Yu, Xudong;Wang, Peng
关键词：photosynthetic characteristics; osmotic adjustment; enzyme activity; genetic identification; RT-qPCR
-
Transcriptome and Metabolome Analyses Reveal the Involvement of Multiple Pathways in Flowering Intensity in Mango
作者：Liang, Qingzhi;Song, Kanghua;Lu, Mingsheng;Dai, Tao;Wan, Jiaxin;Li, Li;Chen, Jingjing;Wang, Songbiao;Lu, Mingsheng;Dai, Tao;Yang, Jie;Wan, Jiaxin;Zhan, Rulin
关键词：FLOWERING LOCUS; flowering mechanism; inflorescence; light quality pathway; photoperiod pathway; reproductive phase; vernalization pathway
-
Distribution and determinants of organic carbon and available nutrients in tropical paddy soils revealed by high-resolution sampling
作者：Zhang, Huan;Zhang, Huan;Su, Baowei;Shao, Shuangshuang;Yang, Jie;Fan, Manman;Wu, Jingtao;Gao, Chao;Wang, Dengfeng;Zhang, Huan
关键词：Soil fertility; Cropping system; High-resolution sampling; Random Forest; Tropical paddy soil
-
The complete mitochondrial genome of upland rice (Oryza sativa) in southwest of China
作者：Xu, Jianxin;Yang, Jie
关键词：Oryza sativa; mitochondrial genome; phylogenetic analysis
-
The complete mitogenome of wild honeybee Apis dorsata (Hymenoptera: Apidae) from South-Western China
作者：Yang, Jie;Xu, Jianxin;Wu, Jie;Zhang, Xuan;He, Shaoyu
关键词：Apis dorsata; mitochondrial genome; phylogenetic analysis
