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Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory response and apoptosis in liver of Monopterus albus

文献类型： 外文期刊

作者： Shi, Yong 1 ; Zhong, Lei 1 ; Fan, Yuding 3 ; Zhang, Junzhi 1 ; Dai, Jihong 1 ; Zhong, Huan 1 ; Fu, Guihong 1 ; Hu, Yi 1 ;

作者机构： 1.Hunan Agr Univ, Hunan Res Ctr Engn Technol Utilizat Distinct Aquat, Changsha 410128, Peoples R China

2.Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Peoples R China

3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

4.Hunan Agr Univ, Changsha 410128, Peoples R China

关键词： Rice field eel; Antioxidant; Immune; Autophagy; Hepatotoxicity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.622； 五年影响因子：4.799 ）

ISSN： 1050-4648

年卷期： 2022 年 128 卷

页码：

收录情况： SCI

摘要： Fish are extremely vulnerable to environmental stimulation and produce oxidative stress. Among them, hydrogen peroxide is an oxidative stress source that cannot be ignored in fish, which can cause physical disorders, inflammation and even death. Taurine was revealed to reduce oxidative damage and inflammation caused by toxic substances, but whether it can reduce toxicity of rice field eel caused by H2O2 has not been determined. Thus, the intervention effects of taurine on H2O2-induced oxidative stress, inflammation, apoptosis, and auto-phagy in rice field eel. The results showed that oxidative injury in the liver was determined after H2O2 injection, as indicated by enhanced serum AST and ALT activities, inhibited the antioxidant function (increased MDA and ROS contents, decreased antioxidant enzymes, inhibited nrf2 transcription level), and induced inflammatory response (upregulated il-1 beta, il-6, il-8, and il-12 beta gene expression, downregulated tgf-beta 1 gene expression, activated the transcription level of nf-kappa b, tlr-3, and tlr-7). In addition, bax, caspase3, beclin1, and Lc3B gene expression were significantly upregulated after H2O2 injection, while bcl2 and p62 gene expression were downregulated, leading to the occurrence of apoptosis and autophagy. In contrast, adding 0.2 and 0.5% taurine to feed significantly alleviated this damage, as indicated by the recovery of the aforementioned bioindicators, and the effect of 0.5% taurine addition is better than 0.2%. Overall, these results suggested that taurine can relieve the liver toxicity induced by H2O2, which enriched the toxic mechanism of H2O2 on fish and provided evidence for the protective effect of taurine on liver.

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