您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Comparison of the diagnostic effectiveness of ultrasound imaging coupled with three mathematical models for discriminating thyroid nodules

文献类型： 外文期刊

作者： Li, Lu 1 ; Deng, Hongyan 1 ; Chen, Wenqin 1 ; Wu, Liuxi 1 ; Li, Yong 3 ; Wang, Jie 2 ; Ye, Xinhua 1 ;

作者机构： 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Nanjing 210029, Peoples R China

2.Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, Nanjing, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing, Peoples R China

关键词： Ultrasound; thyroid nodule; mathematical model; logistic regression; partial least squares discriminant analysis; support vector machine

期刊名称：ACTA RADIOLOGICA （ 2022影响因子：1.3； 五年影响因子：1.5 ）

ISSN： 0284-1851

年卷期： 2024 年 65 卷 5 期

页码：

收录情况： SCI

摘要： Background: The overlapping nature of thyroid lesions visualized on ultrasound (US) images could result in misdiagnosis and missed diagnoses in clinical practice. Purpose: To compare the diagnostic effectiveness of US coupled with three mathematical models, namely logistic regression (Logistics), partial least-squares discriminant analysis (PLS-DA), and support vector machine (SVM), in discriminating between malignant and benign thyroid nodules. Material and Methods: A total of 588 thyroid nodules (287 benign and 301 malignant) were collected, among which 80% were utilized for constructing the mathematical models and the remaining 20% were used for internal validation. In addition, an external validation cohort comprising 160 nodules (80 benign and 80 malignant) was employed to validate the accuracy of these mathematical models. Results: Our study demonstrated that all three models exhibited effective predictive capabilities for distinguishing between benign and malignant nodules, whose diagnostic effectiveness surpassed that of the TI-RADS classification, particularly in terms of true negative diagnoses. SVM achieved a higher diagnostic rate for malignant thyroid nodules (93.8%) compared to Logistics (91.5%) and PLS-DA (91.6%). PLS-DA exhibited higher diagnostic rates for benign thyroid nodules (91.9%) compared to Logistics (86.7%) and SVM (88.7%). Both the area under the receiver operating characteristic curve (AUC) values of PLS-DA (0.917) and SVM (0.913) were higher than that of Logistics (0.891). Conclusion: Our findings indicate that SVM had significantly higher rates of true positive diagnoses and PLS-DA exhibited significantly higher rates of true negative diagnoses. All three models outperformed the TI-RADS classification in discriminating between malignant and benign thyroid nodules.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台