文献类型： 外文期刊

作者： Zhao, Wenjing ¹ ; Ren, Aiqi ² ; Shan, Shuhua ¹ ; Li, Zhuoyu ¹ ; Su, Ruijun ² ; Yang, Ruipeng ² ; Zhai, Feihong ² ; Wu, Lihua ² ; Tang, Zhaohui ³ ; Yang, Jieya ² ; Yue, Linzhong ² ;

作者机构： 1.Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China

2.Taiyuan Normal Univ, Biol Sci & Technol Coll, Jinzhong 030619, Peoples R China

3.Shanxi Acad Agr Sci, Taiyuan 030006, Peoples R China

关键词： colorectal cancer; foxtailmillet; solubledietary fiber; gut microbiome; AOM/DSS

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 21 期

页码：

收录情况： SCI

摘要： Colorectal cancer (CRC) is a common malignant tumor that occurs in the colon. Gut microbiota is a complex ecosystem that plays an important role in the pathogenesis of CRC. Our previous studies showed that the soluble dietary fiber of foxtail millet (FMB-SDF) exhibited significant antitumor activity in vitro. The present study evaluated the anticancer potential of FMB-SDF in the azoxymethane (AOM)- and dextran sodium sulfate (DSS)-induced mouse CRC models. The results showed that FMB-SDF could significantly alleviate colon cancer symptoms in mice. Further, we found that FMB-SDF consumption significantly altered gut microbiota diversity and the overall structure and regulated the abundance of some microorganisms in CRC mice. Meanwhile, KEGG pathway enrichment showed that FMB-SDF can also alleviate the occurrence of colon cancer in mice by regulating certain cancer-related signaling pathways. In conclusion, our findings may provide a novel approach for the prevention and biotherapy of CRC.