文献类型： 外文期刊
作者： Chen, Yihe 1 ; Peng, Wei 2 ; Zhang, Zijing 3 ; Liu, Xian 4 ; Yang, Peng 1 ; Fu, Changqi 2 ; Zhang, Jun 1 ; Wang, Hongli 5 ; Zhou, Sensen 5 ; Lei, Chuzhao 1 ; Wang, Eryao 3 ; Huang, Yongzhen 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
2.Qinghai Univ, Qinghai Acad Anim Sci & Vet Med, Xining 810016, Peoples R China
3.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China
4.Henan Prov Anim Husb Gen Stn, Zhengzhou 450008, Henan, Peoples R China
5.Jiaxian Anim Husb Bur, Jiaxian 467100, Henan, Peoples R China
6.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
关键词： Cattle; Copy number variations; MUC19 gene; Association analysis
期刊名称：GENE （ 影响因子：3.5； 五年影响因子：3.3 ）
ISSN： 0378-1119
年卷期： 2023 年 851 卷
页码：
收录情况： SCI
摘要： Copy number variation (CNV), as one of the important variations in the biological genome, refers to the deletion and duplication of genomic segments between 1 kb and 50 kb caused by genomic rearrangements. Currently, many copy number variations have been found to be significantly associated with important economic traits such as growth, development and reproduction of cattle. However, the study of MUC19 gene has not been reported. In this study, we detected an appropriate correlation between MUC19 gene and growth traits of Chinese cattle. We detected the distribution of MUC19-CNV across Qinchuan cattle (QC), Pinan cattle (PN), Xianan cattle (XN), Yunling cattle (YL), Guyuan cattle (GY), Jiaxian cattle (JX), and analyzed the association between types of MUC19-CNV and growth traits through SPSS20.0 software and method of ANOVA. The results showed that various types of CNV were present in each breed of cattle, but there were discrepancies in the distribution of copy number variant types. The Association analysis result showed that CNV of MUC19 gene showed a postive effect in cattle growth traits: the copy number of MUC19 was significantly correlated with hip width of PN cattle (P < 0.01), height at hip cross and withers height of PN cattle (P < 0.05), hip width and body length of JX cattle (P < 0.05), Huckle bone width of YL cattle (P < 0.05).
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