Trace analysis of 20 antihistamines in milk by ultrahigh performance liquid chromatography coupled with high field quadrupole orbitrap high resolution mass spectrometry followed dispersive micro solid phase extraction
文献类型： 外文期刊
作者： Decheng, Suo 1 ; Zhanteng, Song 2 ; Zhiming, Xiao 1 ; Yang, Li 1 ; Wuyan, Liu 3 ; Junming, Wang 3 ; Xia, Fan 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, 12 Zhongguancun South St, Beijing 100081, Peoples R China
2.Xinjiang Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Urumqi 830091, Peoples R China
3.Shaanxi Qinyun Agr Prod Inspection & Testing Co Lt, Shaanxi 714299, Peoples R China
关键词： Antihistamines; Milk; High-field quadrupole-orbitrap high resolution; mass spectrometry; Dispersive micro solid phase extraction
期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.1； 五年影响因子：3.7 ）
ISSN： 0021-9673
年卷期： 2024 年 1727 卷
页码：
收录情况： SCI
摘要： Ultrahigh-performance liquid chromatography coupled with high-field quadrupole Orbitrap high resolution mass spectrometry was used for the separation and determination of 20 antihistamines, and a dispersive micro solidphase extraction procedure using high-performance absorbing material was developed as a sample preparation strategy for extracting 20 antihistamines from milk. Instrument conditions and key parameters influencing extraction efficiency were investigated to obtain an optimized method. The limit of detection for 20 antihistamines in milk using this method is 0.05 mu g/L to 1.0 mu g/L. Recoveries are between 80.7 % and 108.3 %, and the relative standard deviation is less than 15 %. It is suitable for confirmatory monitoring and quantitative analysis of 20 antihistamines in milk. The results show that antihistamines in milk may be noteworthy issues for human health and environmental pollution.
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