Anti-obesity effects of mulberry leaf extracts on female high-fat diet-induced obesity: Modulation of white adipose tissue, gut microbiota, and metabolic markers
文献类型： 外文期刊
作者： Zhao, Tiantian 1 ; Chen, Qirong 2 ; Chen, Zhang 2 ; He, Taoping 2 ; Zhang, Lijun 1 ; Huang, Qingrong 3 ; Liu, Weifeng 1 ; Zeng, Xi 4 ; Zhang, Yehui 1 ;
作者机构： 1.Minist Agr & Rural Affairs, Sericulture & Agrifood Res Inst, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Guangdong Acad Agr, Guangzhou 510610, Guangdong, Peoples R China
2.Guangzhou Coobase Biotechnol Co Ltd, Guangzhou 511493, Guangdong, Peoples R China
3.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
4.Guangzhou Inst Food Control, Guangzhou 511400, Guangdong, Peoples R China
关键词： Mulberry leaf extraction; Obesity modulation; Adipocytes; Gut microbiota; Antioxidant effects
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）
ISSN： 0963-9969
年卷期： 2024 年 177 卷
页码：
收录情况： SCI
摘要： Mulberry leaves (MLs) are reported to have beneficial effects in modulating obesity in male models. However, the impact of different types of mulberry leaf extracts (MLEs) on female models, specifically their influence on adipocytes, gut microbiota, and related metabolic markers, remains poorly understood. In this study, we observed a strong correlation between the total phenolic content (TPC), antioxidant and adipocyte modulation effects of water extracted MLEs. HB-W (water-extracted baiyuwang) and HY-W (water-extracted Yueshen) demonstrated remarkable inhibition effects on adipocytes in 3 T3-L1 adipocytes model. Moreover, MLEs effectively reduced the levels of triglycerides (TG), non-esterified fatty acids (NEFA), and total cholesterol (T-CHO) in adipocytes in vitro. In vivo experiments conducted on female mice with high fat diet (HFD)-induced obesity revealed the anti-obesity effects of HB-W and HY-W, leading to a significant decrease in weight gain rates and notable influence on the ratios of adipose tissue, particularly white adipose tissue (WAT). Gene expression analysis demonstrated the up-regulation of WAT-related genes (Pla2g2a and Plac8) by HB-W, while HY-W supplementation showed beneficial effects on the regulation of blood sugar-related genes. Furthermore, both HB-W and HY-W exhibited modulatory effects on obesity-related gut microbiota (Firmicutes-to-Bacteroidetes ratio) and short chain fatty acid (SCFA) contents. Importantly, they also mitigated abnormalities in liver function and uncoupling protein 1 (UPC1) expression. Overall, our findings underscore the anti-obesity effects of MLEs in female rats with high-fat diet-induced obesity.
- 相关文献
作者其他论文 更多>>
-
Effects of alkaline water-assisted tea polyphenol soaking on the physicochemical, biochemical, bacterial structure, and free amino acid composition of grass carp fillets during storage at 4 °C
作者：Lin, Yilin;Zhang, Yehui;Lin, Yilin;Xuan, Xie;Yu, Yigang;Huang, Lihua;Fabrice, Kabore Manegdebwaoga Arthur
关键词：Tea polyphenols; Alkaline water; Bacterial structure; Free amino acid; Grass carp fillets
-
Analysis of differential metabolites in Liuyang douchi at different fermentation stages based on untargeted metabolomics approach
作者：Jiang, Liwen;Chen, Yi;Li, Pao;Liao, Luyan;Liu, Yang;Jiang, Liwen;Chen, Yi;Li, Pao;Liao, Luyan;Zhao, Tiantian
关键词：Liuyang douchi; Metabolic profiles; Fermentation process; Untargeted metabolomics; Flavor metabolites
-
Effect of smoke processing on the proteins and volatile compounds and their interactions in skipjack tuna
作者：Hu, Wenjin;Cao, Chenchen;Long, Yinghui;Zheng, Jiabao;Sun, Weizheng;Su, Guowan;Zhao, Tiantian;Huo, Menglan;Huo, Guochang
关键词：Sliced-smoked skipjack tuna; Protein structure; Volatile flavor compounds; GC-MS; PLSR
-
Influence of catechin-PAYCS interactions on gastrointestinal structural and bioactivity stability: Key mechanisms in digestive enzymes inhibition
作者：Chen, Jieqiong;Lin, Chunyan;Yang, Lijia;Zhang, Yehui;Liu, Weifeng;Zhao, Tiantian;Chen, Jieqiong;Su, Guowan;Zhao, Mouming;Yang, Lijia;Liu, Yang;Zhao, Xuan;Huang, Lihua
关键词：Pentapeptide; Catechin; Non-covalent/covalent interaction; Acetylcholinesterase (AChE); Gastrointestinal digestion
-
Optimizing decolorization and deodorization to remove pigments and fishy odors while preserving antioxidant activity in Asian swamp eel (Monopterus albus) hydrolysate
作者：Wang, Xiao;Liu, Hongru;He, Hui;Luo, Xinyu;Chen, Bingjie;Yang, Hang;Zhou, Wenzong;Zhao, Tiantian;Bhullar, Khushwant S.;Su, Di
关键词：ASE hydrolysate; Activated carbon; Decolorization; Encapsulation; Deodorization
-
Effects of immersion with electro-activated alkaline water on gel properties, biochemicals and odor characteristics of myofibrillar proteins
作者：Lin, Yilin;Li, Xiaoqing;Wang, Chun;Yu, Yigang;Lin, Yilin;Zhang, Yehui;Huang, Lihua;Wang, Jili
关键词：Myofibrillar proteins; Alkaline water; Surimi gels; Water distribution; Microstructure; Volatile compounds
-
Degree of methyl esterification: A key factor for the encapsulation of icaritin with pectin
作者：Chen, Yipeng;Yang, Bao;Wen, Lingrong;Zhao, Tiantian;Cheng, Lina;Yang, Bao;Chen, Yipeng;Yang, Bao;Wen, Lingrong
关键词：Characterization; Loading capacity; NMR
