Anti-obesity effects of mulberry leaf extracts on female high-fat diet-induced obesity: Modulation of white adipose tissue, gut microbiota, and metabolic markers
文献类型： 外文期刊
作者： Zhao, Tiantian 1 ; Chen, Qirong 2 ; Chen, Zhang 2 ; He, Taoping 2 ; Zhang, Lijun 1 ; Huang, Qingrong 3 ; Liu, Weifeng 1 ; Zeng, Xi 4 ; Zhang, Yehui 1 ;
作者机构： 1.Minist Agr & Rural Affairs, Sericulture & Agrifood Res Inst, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Guangdong Acad Agr, Guangzhou 510610, Guangdong, Peoples R China
2.Guangzhou Coobase Biotechnol Co Ltd, Guangzhou 511493, Guangdong, Peoples R China
3.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
4.Guangzhou Inst Food Control, Guangzhou 511400, Guangdong, Peoples R China
关键词： Mulberry leaf extraction; Obesity modulation; Adipocytes; Gut microbiota; Antioxidant effects
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）
ISSN： 0963-9969
年卷期： 2024 年 177 卷
页码：
收录情况： SCI
摘要： Mulberry leaves (MLs) are reported to have beneficial effects in modulating obesity in male models. However, the impact of different types of mulberry leaf extracts (MLEs) on female models, specifically their influence on adipocytes, gut microbiota, and related metabolic markers, remains poorly understood. In this study, we observed a strong correlation between the total phenolic content (TPC), antioxidant and adipocyte modulation effects of water extracted MLEs. HB-W (water-extracted baiyuwang) and HY-W (water-extracted Yueshen) demonstrated remarkable inhibition effects on adipocytes in 3 T3-L1 adipocytes model. Moreover, MLEs effectively reduced the levels of triglycerides (TG), non-esterified fatty acids (NEFA), and total cholesterol (T-CHO) in adipocytes in vitro. In vivo experiments conducted on female mice with high fat diet (HFD)-induced obesity revealed the anti-obesity effects of HB-W and HY-W, leading to a significant decrease in weight gain rates and notable influence on the ratios of adipose tissue, particularly white adipose tissue (WAT). Gene expression analysis demonstrated the up-regulation of WAT-related genes (Pla2g2a and Plac8) by HB-W, while HY-W supplementation showed beneficial effects on the regulation of blood sugar-related genes. Furthermore, both HB-W and HY-W exhibited modulatory effects on obesity-related gut microbiota (Firmicutes-to-Bacteroidetes ratio) and short chain fatty acid (SCFA) contents. Importantly, they also mitigated abnormalities in liver function and uncoupling protein 1 (UPC1) expression. Overall, our findings underscore the anti-obesity effects of MLEs in female rats with high-fat diet-induced obesity.
- 相关文献
作者其他论文 更多>>
-
Formation of Volatile Pyrazinones in the Asparagine Maillard Reaction Systems and Novel Pyrazinone Formation Pathways in the Amidated-Alanine Maillard Reaction Systems
作者：Luo, Yue;Li, Run;Zhu, Siyue;Peng, Jie;Huang, Qingrong;Ho, Chi-Tang;Zhao, Tiantian
关键词：Maillard reaction; asparagine; alanine; amidation; pyrazinones
-
Anti-skin aging effects of mulberry fruit extracts: In vitro and in vivo evaluations of the anti-glycation and antioxidant activities
作者：Zhang, Lijun;Yu, Mengjie;Zhang, Yehui;Zhao, Tiantian;Chen, Qirong;Chen, Zhang;He, Taoping;Zhang, Lijun;Yu, Mengjie;Nan, Haijun;Huang, Qingrong;Zhao, Tiantian
关键词：Mulberry fruit extract; AGEs; Oxidative stress; Anti-glycation; Anti -skin aging
-
Degree of methyl esterification: A key factor for the encapsulation of icaritin with pectin
作者：Chen, Yipeng;Yang, Bao;Wen, Lingrong;Zhao, Tiantian;Cheng, Lina;Yang, Bao;Chen, Yipeng;Yang, Bao;Wen, Lingrong
关键词：Characterization; Loading capacity; NMR
-
Occurrence of Leaf Spot on Elaeocarpus decipiens Caused by Alternaria alternata, a New Disease in China
作者：Liu, Jun;Zhou, Shengyang;Zhang, Yehui;Lian, Lingdan
关键词：Alternaria alternata; Elaeocarpus decipiens; leaf spot
-
Anti-Psoriatic Activity of Black, Green and White Tea Extracts from Southeastern China
作者：Huang, Zeting;Xuan, Jie;Yang, Lu;Peng, Weihua;Zhang, Lanyue;Zhao, Tiantian;Zhao, Tiantian
关键词：psoriasis; tea; inflammation; ethanol extract; component analysis
-
The antibacterial mechanism of (-)-epigallocatechin-3-gallate (EGCG) against Campylobacter jejuni through transcriptome profiling
作者：Lin, Yilin;Liang, Siwei;Yu, Yigang;Zhang, Yehui;Zhang, Yehui
关键词：antibacterial mechanism; campylobacter jejuni; (-)-Epigallocatechin-3-gallate; iron deficiency; motility; RNA-sequencing
-
Tea for histamine anti-allergy: component analysis of tea extracts and potential mechanism for treating histamine anti-allergy
作者：Huang, Zeting;Xuan, Jie;Yang, Lu;Peng, Weihua;Zhang, Lanyue;Zhao, Tiantian;Zhao, Tiantian
关键词：camellia; chemical compositions; histamine; anti-allergic dermatitis; anti-oxidation; anti-inflammation
