Efficient Inhibition of Streptococcus agalactiae by AIEgen-Based Fluorescent Nanomaterials
文献类型： 外文期刊
作者： Yi, Mengmeng 1 ; Wang, He 1 ; Wang, Miao 1 ; Cao, Jianmeng 1 ; Gao, Fengying 1 ; Ke, Xiaoli 1 ; Liu, Zhigang 1 ; Liu, Yin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst,Minist Agr, Key Lab Trop & Subtrop Fishery Resource Applicat, Guangdong Prov Key Lab Aquat Anim Immune Technol, Guangzhou, Peoples R China
2.Dalian Ocean Univ, Key Lab Environm Controlled Aquaculture, Minist Educ, Dalian, Peoples R China
关键词： aggregation induced emission; TBP-1; Streptococcus agalactiae; antimicrobial activity; ROS
期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）
ISSN： 2296-2646
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： Streptococcus agalactiae, referred to as group B streptococcus (GBS), is a prominent co-pathogenic bacterium causing the onset and death of human, animal, and aquatic products. Although antibiotics are efficient against GBS, antibiotic resistance through antibiotic overuse is an equally serious problem. Therefore, the treatment of GBS infection appears strongly dependent on nonantibiotic therapy, such as photodynamic therapy. Different from other photosensitizers (PSs), luminogens with aggregation-induced emission (AIEgen) can efficiently generate fluorescence and reactive oxygen species (ROS). Herein, TBP-1, an efficient AIE PSs, is chosen to resist GBS, and its antibacterial activity and the killing mechanism toward GBS are investigated. The ROS generation performance and the images of GBS treated with TBP-1 in the dark or under white light irradiation were investigated. TBP-1 with its high ROS generation ability can efficiently kill GBS and serve as a novel treatment strategy against GBS infection.
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