Comparison of four characteristic carotenoids (lutein, β-carotene, lycopene, and astaxanthin) in alleviating DSS-induced colitis through gut microbiota regulation
文献类型： 外文期刊
作者： Dong, Yangyang 1 ; Ni, Qianjin 1 ; Zhang, Zhi 1 ; Yu, Zhaoqing 1 ; Feng, Lei 1 ; Xu, Yayuan 1 ; Lian, Yunhe 3 ; Zhou, Cunshan 2 ; Li, Dajing 1 ; Dai, Zhuqing 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
3.Chenguang Biotech Grp Co Ltd, Handan 057250, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.4； 五年影响因子：6.1 ）
ISSN： 2042-6496
年卷期： 2025 年 16 卷 15 期
页码：
收录情况： SCI
摘要： Carotenoids, particularly lutein, beta-carotene, lycopene, and astaxanthin, possess established anti-inflammatory and antioxidant properties. Although these compounds are known to interact with the gut microbiota and ameliorate microbial dysbiosis, their structure-activity relationships in colitis alleviation remain poorly understood. Using a dextran sulfate sodium (DSS)-induced colitis model, we made a systematic comparison of these four structurally distinct carotenoids. All treatments markedly improved colitis-associated clinical symptoms, including weight loss, colon shortening, bloody stool, and histological damage. Notably, the fecal heme content decreased by 55.00%, 69.44%, 60.22%, and 62.24% in the lutein, beta-carotene, lycopene, and astaxanthin groups by the endpoint of DSS exposure, respectively. The intervention with carotenoids significantly reduced pro-inflammatory markers while upregulating intestinal tight junction proteins and short-chain fatty acid receptor expression. 16S rRNA sequencing revealed consistent suppression of Bilophila and Mucispirillum across all groups, with structure-dependent microbiota modulation: lutein enriched Rikenellaceae, beta-carotene enhanced Bifidobacteriaceae, lycopene preferentially increased Lactobacillaceae, and astaxanthin elevated Akkermansiaceae (in terms of relative abundance). These findings demonstrate that carotenoids alleviate ulcerative colitis through combined anti-inflammatory, barrier-protective, and microbiota-modulating effects, with carotenes exhibiting superior microbiota modulation compared to xanthophylls.
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