Genome Assessment of Carbapenem- and Colistin-Resistant Escherichia coli from Patients in a Sentinel Hospital in China
文献类型： 外文期刊
作者： Ma, Jiangang 1 ; Tang, Biao 1 ; Lin, Jiahui 1 ; Ed-Dra, Abdelaziz 3 ; Lin, Hui 1 ; Wu, Jing 1 ; Dong, Yuzhi 1 ; Yang, Hua 1 ; Yue, Min 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China
3.Zhejiang Univ, Hainan Inst, Sanya 572025, Peoples R China
4.Zhejiang Univ, Inst Prevent Vet Sci, Coll Anim Sci, Hangzhou 310058, Peoples R China
5.Zhejiang Univ, Dept Vet Med, Coll Anim Sci, Hangzhou 310058, Peoples R China
6.Zhejiang Prov Key Lab Prevent Vet Med, Hangzhou 310058, Peoples R China
7.Zhejiang Univ, Affiliated Hosp 1, Coll Med,Natl Med Ctr Infect Dis, Natl Clin Res Ctr Infect Dis,State Key Lab Diag &, Hangzhou 310058, Peoples R China
关键词： bla (NDM); Escherichia coli; inpatient; mcr-1; astA
期刊名称：CELLS （ 影响因子：7.666； 五年影响因子：7.677 ）
ISSN：
年卷期： 2022 年 11 卷 21 期
页码：
收录情况： SCI
摘要： Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 E. coli strains from patients between January and July 2021. One bla(NDM-1)-, nine bla(NDM-5)-, and one mcr-1-positive E. coli recovered from inpatients were identified as resistant to meropenem and colistin. There are 37 virulence genes discovered in the 11 strains, including astA in strain EC21Z-147 (O128: H4), which belongs to the enteroaggregative E. coli (EAEC). The bla(NDM) gene is distributed into distinct ST types, including ST48, ST616, ST410, ST711, and ST2003, while the mcr-1 gene was identified in ST117. The conjugative plasmids IncX3, IncI1-I, and IncI2 mediated the bla(NDM-5) and mcr-1 genes detected among inpatients. Notably, the youngest age at which mcr-1-positive E. coli has been reported was at one day old, in a child in which the strain is closely related to strains with animal origins. Hospitals are major environments for the spread and dissemination of critical virulence and AMR genes, which requires active monitoring systems at the genome level to surveil the spread of virulence and AMR.
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