Proteomic profiling of serum extracellular vesicles identifies diagnostic markers for echinococcosis
文献类型： 外文期刊
作者： Guo, Xiaola 1 ; Wang, Shuai 1 ; Zhang, Junmei 1 ; Li, Rui 1 ; Zhang, Yong'e 1 ; Wang, Zhengrong 2 ; Kong, Qingming 3 ; Cho, William C. 4 ; Ju, Xianghong 5 ; Shen, Yujuan 6 ; Zhang, Lingqiang 7 ; Fan, Haining 7 ; Cao, Jianping 6 ; Zheng, Yadong 8 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
3.Hangzhou Med Coll, Sch Biol Engn, Inst Parasit Dis, Hangzhou, Peoples R China
4.Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
5.Guangdong Ocean Univ, Coll Agr, Dept Vet Med, Zhanjiang, Peoples R China
6.Natl Hlth Commiss Peoples Republ China, Key Lab Parasite & Vector Biol, Chinese Ctr Trop Dis Res, Natl Inst Parasit Dis,Chinese Ctr Dis Control & P, Shanghai, Peoples R China
7.Qinghai Univ, Dept Hepatopancreatobiliary Surg, Qinghai Prov Key Lab Hydatid Dis Res, Affiliated Hosp, Xining, Peoples R China
8.Zhejiang A&F Univ, Key Lab Appl Technol Green Ecohlth Anim Husb Zhej, Zhejiang Prov Engn Lab Anim Hlth Inspect & Intern, Zhejiang Int Sci & Technol Cooperat Base Vet Med, Hangzhou, Peoples R China
9.Zhejiang A&F Univ, Coll Vet Med, Hangzhou, Peoples R China
期刊名称：PLOS NEGLECTED TROPICAL DISEASES （ 影响因子：3.8； 五年影响因子：4.1 ）
ISSN： 1935-2735
年卷期： 2022 年 16 卷 10 期
页码：
收录情况： SCI
摘要： Echinococcosis is a parasitic disease caused by the metacestodes of Echinococcus spp. The disease has a long latent period and is largely underdiagnosed, partially because of the lack of effective early diagnostic approaches. Using liquid chromatography-mass spectrometry, we profiled the serum-derived extracellular vesicles (EVs) of E. multilocularis-infected mice and identified three parasite-origin proteins, thioredoxin peroxidase 1 (TPx-1), transitional endoplasmic reticulum ATPase (TER ATPase), and 14-3-3, being continuously released by the parasites into the sera during the infection via EVs. Using ELISA, both TPx-1 and TER ATPase were shown to have a good performance in diagnosis of experimental murine echinococcosis as early as 10 days post infection and of human echinococcosis compared with that of control. Moreover, TER ATPase and TPx-1 were further demonstrated to be suitable for evaluation of the prognosis of patients with treatment. The present study discovers the potential of TER ATPase and TPx-1 as promising diagnostic candidates for echinococcosis.
- 相关文献
作者其他论文 更多>>
-
Multi-Omics Analysis of the Effects of Soil Amendment on Rapeseed (Brassica napus L.) Photosynthesis under Drip Irrigation with Brackish Water
作者：Li, Ziwei;Fan, Hua;Yang, Le;Wang, Shuai;Hong, Dashuang;Cui, Wenli;Wang, Tong;Wei, Chunying;Sun, Yan;Wang, Kaiyong;Liu, Yantao
关键词：brackish water; metabolic pathways; energy metabolism; abiotic stresses; multi-omics
-
Evaluation of protective immune responses induced by DNA vaccines encoding Echinococcus granulosus EgM123 protein in Beagle dogs
作者：Wang, Ning;Xian, Jinwen;Zhao, Pengpeng;Zhao, Wenqing;Pu, Na;Jia, Xinyue;Zhang, Yanyan;Bo, Xinwen;Wang, Zhengrong;Wang, Ning;Xian, Jinwen;Zhao, Pengpeng;Zhao, Wenqing;Pu, Na;Jia, Xinyue;Bo, Xinwen;Wang, Zhengrong;Wang, Ning;Xian, Jinwen;Zhao, Pengpeng;Pu, Na;Jia, Xinyue;Bo, Xinwen;Zhao, Wenqing
关键词：Echinococcus granulosus; EgM123; DNA vaccine; definitive-host; worm burden
-
An epidemiological survey of bovine piroplasmosis in Kashgar, Xinjiang, China
作者：Zhang, Yuxia;Chen, Xuke;Pu, Na;Bo, Xinwen;Zhang, Yuxia;Chen, Xuke;Zhang, Yanyan;Pu, Na;Zhao, Wenqing;Wang, Zhengrong;Sun, Yan;Bo, Xinwen;Jia, Chunying
关键词：Tick-borne disease; Bovine piroplasmosis; Prevention and control; PCR
-
RNA sequencing reveals dynamic expression of genes related to innate immune responses in canine small intestinal epithelial cells induced by Echinococcus granulosus protoscoleces
作者：Wang, Zhengrong;Pu, Na;Zhao, Wenqing;Chen, Xuke;Zhang, Yanyan;Sun, Yan;Bo, Xinwen;Wang, Zhengrong;Pu, Na;Zhao, Wenqing;Chen, Xuke;Zhang, Yanyan;Sun, Yan;Bo, Xinwen;Pu, Na;Chen, Xuke;Bo, Xinwen;Zhao, Wenqing
关键词：
Echinococcus granulosus ; definitive host; innate immunity; pattern recognition receptors; RNA sequencing -
Global profiling of the proteome, phosphoproteome, and N-glycoproteome of protoscoleces and adult worms of Echinococcus granulosus
作者：Wang, Zhengrong;Jia, Xinyue;Ma, Jing;Zhang, Yanyan;Sun, Yan;Bo, Xinwen;Wang, Zhengrong;Jia, Xinyue;Ma, Jing;Zhang, Yanyan;Sun, Yan;Bo, Xinwen;Jia, Xinyue;Ma, Jing;Bo, Xinwen
关键词：Echinococcus granulosus; protoscoleces; adult worm; proteome; phosphoproteome; N-glycoproteome
-
Peroxisome Proliferator-Activated Receptor γ Regulates Lipid Metabolism in Sheep Trophoblast Cells through mTOR Pathway-Mediated Autophagy
作者：Hao, Kexing;Wang, Jing;Wang, Zhengrong;Hao, Kexing;Wang, Jing;Yu, Hengbin;Chen, Lei;Zeng, Weibin;Hu, Guangdong
关键词：
-
FABP4 mediates endoplasmic reticulum stress and autophagy to regulate endometrial epithelial cell function during early sheep gestation
作者：Song, Meijun;Hao, Kexing;Qi, Fenghua;Wang, Jing;Hu, Guangdong;Zhao, Wenjuan;Wang, Zhengrong
关键词：Autophagy; Endometrial epithelial cells; Endoplasmic reticulum stress; Fatty acid-binding protein; Implantation
