Proteomic profiling of serum extracellular vesicles identifies diagnostic markers for echinococcosis
文献类型： 外文期刊
作者： Guo, Xiaola 1 ; Wang, Shuai 1 ; Zhang, Junmei 1 ; Li, Rui 1 ; Zhang, Yong'e 1 ; Wang, Zhengrong 2 ; Kong, Qingming 3 ; Cho, William C. 4 ; Ju, Xianghong 5 ; Shen, Yujuan 6 ; Zhang, Lingqiang 7 ; Fan, Haining 7 ; Cao, Jianping 6 ; Zheng, Yadong 8 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
3.Hangzhou Med Coll, Sch Biol Engn, Inst Parasit Dis, Hangzhou, Peoples R China
4.Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
5.Guangdong Ocean Univ, Coll Agr, Dept Vet Med, Zhanjiang, Peoples R China
6.Natl Hlth Commiss Peoples Republ China, Key Lab Parasite & Vector Biol, Chinese Ctr Trop Dis Res, Natl Inst Parasit Dis,Chinese Ctr Dis Control & P, Shanghai, Peoples R China
7.Qinghai Univ, Dept Hepatopancreatobiliary Surg, Qinghai Prov Key Lab Hydatid Dis Res, Affiliated Hosp, Xining, Peoples R China
8.Zhejiang A&F Univ, Key Lab Appl Technol Green Ecohlth Anim Husb Zhej, Zhejiang Prov Engn Lab Anim Hlth Inspect & Intern, Zhejiang Int Sci & Technol Cooperat Base Vet Med, Hangzhou, Peoples R China
9.Zhejiang A&F Univ, Coll Vet Med, Hangzhou, Peoples R China
期刊名称：PLOS NEGLECTED TROPICAL DISEASES （ 影响因子：3.8； 五年影响因子：4.1 ）
ISSN： 1935-2735
年卷期： 2022 年 16 卷 10 期
页码：
收录情况： SCI
摘要： Echinococcosis is a parasitic disease caused by the metacestodes of Echinococcus spp. The disease has a long latent period and is largely underdiagnosed, partially because of the lack of effective early diagnostic approaches. Using liquid chromatography-mass spectrometry, we profiled the serum-derived extracellular vesicles (EVs) of E. multilocularis-infected mice and identified three parasite-origin proteins, thioredoxin peroxidase 1 (TPx-1), transitional endoplasmic reticulum ATPase (TER ATPase), and 14-3-3, being continuously released by the parasites into the sera during the infection via EVs. Using ELISA, both TPx-1 and TER ATPase were shown to have a good performance in diagnosis of experimental murine echinococcosis as early as 10 days post infection and of human echinococcosis compared with that of control. Moreover, TER ATPase and TPx-1 were further demonstrated to be suitable for evaluation of the prognosis of patients with treatment. The present study discovers the potential of TER ATPase and TPx-1 as promising diagnostic candidates for echinococcosis.
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