tRNA selectivity during ribosome- associated quality control regulates the critical sterility- inducing temperature in two- line hybrid rice
文献类型： 外文期刊
作者： Zhou, Can 1 ; Liu, Chunyan 1 ; Yan, Bin 1 ; Sun, Jing 1 ; Li, Shengdong 1 ; Li, Ji 1 ; Wang, Jia 1 ; Huang, Xiahe 1 ; Yan, Wei 4 ; Yang, Shuying 1 ; Fu, Chenjian 5 ; Qin, Peng 5 ; Fu, Xingxue 5 ; Zhao, Xinghui 5 ; Wu, Yaxian 5 ; Song, Xianwei 1 ; Wang, Yingchun 1 ; Qian, Wenfeng 1 ; Yang, Yuanzhu 5 ; Cao, Xiaofeng 1 ;
作者机构： 1.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Beijing Acad Agr & Forestry Sci, Inst Biotechnol, Beijing Key Lab Agr Genet Resources & Biotechnol, Beijing 100097, Peoples R China
4.Southern Univ Sci & Technol, Inst Plant & Food Sci, Dept Biol, Shenzhen 518055, Peoples R China
5.Yuan LongPing High Tech Agr Co Ltd, Changsha 410125, Peoples R China
6.Minist Agr & Rural Affairs, Key Lab Rice Germplasm Enhancement Southern China, Changsha 410001, Hunan, Peoples R China
关键词： critical sterility-inducing temperature (CSIT); ribosome- associated quality control (RQC); C-terminal alanine and threonine modification (CATylation); OsRqc2; tRNA
期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.1； 五年影响因子：10.6 ）
ISSN： 0027-8424
年卷期： 2025 年 122 卷 6 期
页码：
收录情况： SCI
摘要： The two- line hybrid rice system, a cutting- edge hybrid rice breeding technology, has greatly boosted global food security. In thermo- sensitive genic male sterile (TGMS) lines, the critical sterility- inducing temperature (CSIT; the temperature at which TGMS lines change from male fertile to complete male sterile) acts as a key threshold. We recently uncovered that thermo- sensitive genic male sterility 5 (tms5), a sterile locus presenting in over 95% of TGMS lines, leads to the overaccumulation of 2 ',3 '- cyclic phosphate (cP)-OCCA-tRNAs and a deficiency of mature tRNAs, which underlies the molecular mechanism of tms5- mediated TGMS. However, there are a few reports on the regulatory mechanism controlling CSIT. Here, we identified a suppressor of tms5, an amino acid substitution (T552I) in the rice Rqc2 (ribosome- associated quality control 2), increases the CSIT in tms5 lines through its C- terminal alanine and threonine modification (CATylation) activity.This substitution alters tRNA selectivity, leading to the recruitment of different tRNAs to the A- site of ribosome and CATylation rate by OsRqc2 during ribosome- associated quality control (RQC), a process that rescues stalled ribosomes and degrades abnormal nascent chains during translational elongation. Further, the mutation restores the levels of mature tRNA-Ser/Ile to increase the CSIT of tms5 lines. Our findings reveal the origin of overaccumulated cP-OCCA-tRNAs in tms5 lines, further deepening our understanding of the regulatory network in governing CSIT of TGMS lines containing tms5.
- 相关文献
作者其他论文 更多>>
-
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang
关键词：metagenome; microbiome; microbiota; pipeline; visualization
-
Microplastic-Derived Dissolved Organic Matter Regulates Soil Carbon Respiration via Microbial Ecophysiological Controls
作者：Wang, Jie;Sun, Yuanze;Tao, Jianguo;Tanentzap, Andrew J.;Shi, Jia;Wang, Xiang;Xu, Li;Ding, Jia;Feng, Bing;Gao, Jing;Zhang, Dayi;Cao, Xiaofeng
关键词：MP-DOM; NOM; microplastics; CUE; single-cell Raman spectroscopy; CO2 emissions
-
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines
作者：Zhou, Can;Yan, Bin;Liu, Chunyan;Sun, Jing;Cao, Xiaofeng;Liu, Chunyan;Zhou, Can;Cao, Xiaofeng;Sun, Jing;Yang, Yuanzhu;Yang, Yuanzhu;Yang, Yuanzhu
关键词：critical sterility-inducing temperature; ribosome-associated quality control; OsRqc1-OsVms1 module; tRNA; natural variations
-
A designer synthetic chromosome fragment functions in moss
作者：Chen, Lian-Ge;Zhang, Shuo;Zhang, Yuliang;Du, Qingwei;Jiao, Bingke;Qian, Wenfeng;Jiao, Yuling;Lan, Tianlong;Gao, Yi;Li, Bimeng;Wang, Ying;Qian, Wenfeng;Lan, Tianlong;Lan, Tianlong;Jiao, Yuling;Zhang, Shuo;Zhang, Yuliang;Du, Qingwei;Jiao, Bingke;Jiao, Yuling;Zhao, Mengkai;Hu, Zhangli;Dai, Junbiao;Luo, Guangyu;Ma, Yingxin;Zhao, Qiao;Dai, Junbiao;Luo, Guangyu;Ma, Yingxin;Zhao, Qiao;Dai, Junbiao;Du, Qingwei;Lu, Houze;Dai, Junbiao;Jiao, Yuling;Jiao, Yuling
关键词：
-
Metabolomics analysis of advancing humification mechanism in secondary fermentation of composting by fungal bioaugmentation
作者：Wang, Yuyun;Xu, Zhi;Li, Jun;Chang, Yuan;Chang, Su;Chen, Yanting;Li, Ruoqi;Zheng, Yi;Kang, Zitong;Wu, Zhen;Wei, Yuquan;Li, Ji;Li, Jun;Chang, Yuan;Chen, Yanting;Li, Ruoqi;Kang, Zitong;Wei, Yuquan;Li, Ji;Wei, Dan;Chen, Peizhen
关键词：Humification; Fungal community; Phanerochaete Chrysosporium; pH regulation; Metabolic pathways
-
Impaired 2′,3′-cyclic phosphate tRNA repair causes thermo-sensitive genic male sterility in rice
作者：Yan, Bin;Liu, Chunyan;Sun, Jing;Zhou, Can;Li, Ji;Liu, Wei;Li, Shengdong;Cao, Xiaofeng;Sun, Jing;Mao, Yang;Nie, Jiawei;Gao, Feng;Chen, Yuhang;Zhou, Can;Li, Ji;Li, Shengdong;Nie, Jiawei;Chen, Yuhang;Cao, Xiaofeng;Yan, Wei;Fu, Chenjian;Qin, Peng;Fu, Xingxue;Zhao, Xinghui;Yang, Yuanzhu;Song, Xianwei;Yang, Yuanzhu;Yang, Yuanzhu
关键词：
-
Dietary Tomato Pectin Attenuates Hepatic Insulin Resistance and Inflammation in High-Fat-Diet Mice by Regulating the PI3K/AKT Pathway
作者：Sun, Jing;Wu, Kongyan;Zhang, Chunhong;Sun, Jing;Wu, Kongyan;Wang, Pan;Wang, Yubin;Wang, Dan;Zhao, Wenting;Zhao, Yuanyuan;Zhao, Xiaoyan
关键词：tomato pectin; insulin resistance; PI3K/AKT pathway
