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Longan pulp polysaccharides regulate gut microbiota and metabolites to protect intestinal epithelial barrier

文献类型： 外文期刊

作者： Bai, Yajuan 1 ; Zhou, Yue 3 ; Li, Xiang 1 ; Zhang, Ruifen 4 ; Huang, Fei 4 ; Fan, Bei 1 ; Tong, Litao 1 ; Wang, Fengzhong 1 ; Zhang, Mingwei 4 ;

作者机构： 1.Chinese Acad Agr Sci, Coconstruct Minist & Prov, Inst Food Sci & Technol,Key Lab Genet Resources Ev, Key Lab Agroprod Proc Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

2.Hainan Acad Agr Sci, Sanya Inst, Haikou 572025, Peoples R China

3.Minzu Univ China, Natl Ethn Affairs Commission China, Coll Life & Environm Sci, Key Lab Ecol & Environm Minor Areas, Beijing 100081, Peoples R China

4.Guangdong Acad Agr Sci, Sericultural & Agrifood Res, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Peoples R China

5.Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China

6.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510610, Peoples R China

关键词： Longan pulp polysaccharide; Digestion and fermentation; Intestinal epithelial barrier; Prebiotic effect; Bioavailability

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 422 卷

页码：

收录情况： SCI

摘要： Longan pulp polysaccharide is a bioactive component with prebiotic activity and intestinal barrier protection. This study aimed to evaluate the influence of digestion and fermentation on the bioavailability and intestinal barrier protection of polysaccharide LPIIa from longan pulp. The molecular weight of LPIIa didn't change significantly after gastrointestinal digestion in vitro. After fecal fermentation, 56.02% of LPIIa was consumed by gut microbiota. The short-chain fatty acid level in LPIIa group was 51.63% higher than that in blank group. LPIIa intake also increased short-chain fatty acid production and G-protein-coupled receptor 41 expression in the colon of mice. Moreover, LPIIa improved the relative richness of Lactobacillus, Pediococcus, and Bifidobacterium in colon content. Compared to LPIIa, fecal fermented LPIIa better protected intestinal epithelial barrier by increasing Zonula occludens-1 expression. These results provided an important basis for the design of functional food based on longan polysaccharides to prevent intestinal barrier damage related diseases.

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