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Diluted concentrations of methamphetamine in surface water induce behavior disorder, transgenerational toxicity, and ecosystem-level consequences of fish

文献类型： 外文期刊

作者： Wang, Zhenglu 1 ; Mao, Kang 4 ; Du, Wei 5 ; Cai, Min 6 ; Zhang, Zhaobin 3 ; Li, Xiqing 3 ;

作者机构： 1.Hohai Univ, Minist Nat Resources, Key Lab Marine Hazards Forecasting, Nanjing 210098, Jiangsu, Peoples R China

2.Hohai Univ, Coll Oceanog, Nanjing 210098, Jiangsu, Peoples R China

3.Peking Univ, Coll Urban & Environm Sci, Key Lab Earth Surface Proc, Beijing 100871, Peoples R China

4.Chinese Acad Sci, Inst Geochem, State Key Lab Environm Geochem, Guiyang 550081, Peoples R China

5.East China Normal Univ, Sch Geog Sci, Shanghai 200241, Peoples R China

6.Shanghai Acad Agr Sci, Ecoenvironm Protect Res Inst, Shanghai 201403, Peoples R China

关键词： Emerging pollutant; Transgenerational toxicity; Bioconcentration potential; Environmental concentrations; Ecological risk

期刊名称：WATER RESEARCH （ 影响因子：11.236； 五年影响因子：11.547 ）

ISSN： 0043-1354

年卷期： 2020 年 184 卷

页码：

收录情况： SCI

摘要： Methamphetamine (METH) has been recognized as an emerging organic contaminant as it was widely detected in the aquatic environment via wastewater effluent discharge. However, the ecological hazard posed by METH at environmentally relevant concentrations was remained unclear. In this study, adult medaka fish were exposed to METH at environmental levels (0.05, 0.2, 0.5, 5 mu g L-1) and high level (25 and 100 mu g L-1) for 90 days to investigate its effect on ecologically behavioral functions, histopathology, bioconcentration, and transgenerational toxicity. The significant increase of locomotion activity, total distance, and max velocity of adult medaka were observed at low METH levels (0.2-0.5 mu g L-1), while it markedly decreased at high levels (25-100 mu g L-1). This effect may increase the predation risk of the fish. The significant alteration on the relative expressions of the genes (cacna1c, oxtr, erk1, and c-fos ), as well as the contents of the proteins (oxytocin (OXT) and protein kinase A (PKA)) involved in Volt age Dependent Calcium Channel (VDCC) and Mitogen-Activated Protein Kinase (MAPK) signaling channel induced by METH could partly elucidate the underlying mechanisms of the changes of the behavioral traits. METH could induce obvious minimal gliosis, neuronal loss, and necrotic in brain tissues. Additionally, the significant increase of hepatic-somatic index (HSI) of male medaka at 0.2-5 mu g L-1 groups, and the decrease of female medaka at 100 mu g L-1 group indicated male fish was more susceptible to METH. Nephric-somatic index (NSI) of medaka markedly declined induced by METH at 0.05-100 mu g L-1. The bioconcentration factor (BCF) (0.4-5.8) in medaka fish revealed the bioconcentration potential of METH in fish. This study for the first time demonstrated METH could induced the development defects of larvae in F1 generation at environmentally relevant concentrations, thereby resulting in a significant decrease in the capacity of fish to produce offspring. Meanwhile, the RQ values ( > 1) of METH in river in China, USA, and Australia showed a high teratogenic risk level, suggesting the ecosystem-levels consequence posed by METH should be concerned. (c) 2020 Published by Elsevier Ltd.

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