文献类型： 外文期刊

作者： Xing, Huanwei ¹ ; Ye, Li ⁴ ; Fan, Junwen ⁵ ; Fu, Tingting ² ; Li, Chang ⁶ ; Zhang, Suhua ¹ ; Ren, Linzhu ⁷ ; Bai, Jieying ² ;

作者机构： 1.Hebei Univ Technol, Sch Sci, Inst Biophys, Tianjin, Peoples R China

2.Nanjing Raygen Hlth Mol Med Technol Co Ltd, PKU Nanjing Joint Inst Translat Med, Nanjing, Peoples R China

3.Peking Univ, Nonhuman Primate Res Ctr, Inst Mol Med, 321 Room,Yingjie Exchange Ctr 5,Yiheyuan Rd, Beijing 100871, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Beijing Res Ctr Informat Technol Agr, Beijing, Peoples R China

5.China Beijing Anim Dis Control & Prevent Ctr, Beijing, Peoples R China

6.Acad Mil Med Sci, Mil Vet Inst, Changchun, Jilin, Peoples R China

7.Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Embryo Engn, Changchun 130062, Peoples R China

关键词： African green monkey (AGM); interferon-induced transmembrane protein; mouse norovirus (MNV); severe fever with thrombocytopenia syndrome virus (SFTSV)

期刊名称：VIRAL IMMUNOLOGY （ 影响因子：2.257； 五年影响因子：1.882 ）

ISSN： 0882-8245

年卷期： 2020 年 33 卷 10 期

页码：

收录情况： SCI

摘要： Interferon-induced transmembrane proteins (IFITMs) are transmembrane proteins induced by interferon that can provide broad-spectrum antiviral activities. However, there are few reports on the antiviral activity of monkey-derived IFITMs. In this study, the IFITM1 and IFITM3 genes of African green monkey (AGM) were cloned and overexpressed in Vero cells, followed by infection with mouse norovirus (MNV) and severe fever with thrombocytopenia syndrome virus (SFTSV). The results showed that monkey IFITM1 and IFITM3 can be stably overexpressed in Vero cells. Both IFITM1 and IFITM3 from AGM could effectively restrict infection by SFTSV, and the viral inhibition rate of IFITM3 was more obvious compared with IFITM1. However, both monkey IFITM1 and IFITM3 had no significant effect on the replication of MNV. These results indicate that different IFITMs have different functions, which may be related to the structure of the host IFITMs and the types of pathogens.