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Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

文献类型： 外文期刊

作者： Fu, Yongxia 1 ; Yin, Ruiyang 1 ; Liu, Zhenyu 1 ; Niu, Yan 2 ; Guo, Erhu 3 ; Cheng, Ruhong 4 ; Diao, Xianmin 5 ; Xue, Yong 1 ;

作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn Res Ctr Fruits & Vegetables Proc, Key Lab Plant Prot & Grain Proc, Beijing 100083, Peoples R China

2.Shan Xi Dongfang Wuhua Agr Technol Co Ltd, Datong 037000, Peoples R China

3.Shanxi Acad Agr Sci, Res Inst Millet, Taiyuan 030031, Peoples R China

4.Hebei Acad Agr & Forestry Sci, Res Inst Millet, Shijiazhuang 050035, Hebei, Peoples R China

5.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China

关键词： foxtail millet; gut microbiota; metabolomics; prolamin; type 2 diabetes

期刊名称：NUTRIENTS （ 2020影响因子：5.717； 五年影响因子：6.349 ）

ISSN：

年卷期： 2020 年 12 卷 11 期

页码：

收录情况： SCI

摘要： Millet proteins have been demonstrated to possess glucose-lowering and lipid metabolic disorder modulation functions against diabetes; however, the molecular mechanisms underlying their anti-diabetic effects remain unclear. The present study aimed to investigate the hypoglycemic effect of prolamin from cooked foxtail millet (PCFM) on type 2 diabetic mice, and explore the gut microbiota and serum metabolic profile changes that are associated with diabetes attenuation by PCFM. Our diabetes model was established using a high-fat diet combined with streptozotocin before PCFM or saline was daily administrated by gavage for 5 weeks. The results showed that PCFM ameliorated glucose metabolism disorders associated with type 2 diabetes. Furthermore, the effects of PCFM administration on gut microbiota and serum metabolome were investigated. 16S rRNA gene sequencing analysis indicated that PCFM alleviated diabetes-related gut microbiota dysbiosis in mice. Additionally, the serum metabolomics analysis revealed that the metabolite levels disturbed by diabetes were partly altered by PCFM. Notably, the decreased D-Glucose level caused by PCFM suggested that its anti-diabetic potential can be associated with the activation of glycolysis and the inhibition of gluconeogenesis, starch and sucrose metabolism and galactose metabolism. In addition, the increased serotonin level caused by PCFM may stimulate insulin secretion by pancreatic beta-cells, which contributed to its hypoglycemic effect. Taken together, our research demonstrated that the modulation of gut microbiota composition and the serum metabolomics profile was associated with the anti-diabetic effect of PCFM.

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