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Luzhong mutton sheep: inbreeding and selection signatures

文献类型： 外文期刊

作者： Tao, Lin 1 ; He, Xiaoyun 1 ; Wang, Fengyan 1 ; Zhong, Yingjie 1 ; Pan, Linxiang 2 ; Wang, Xiangyu 1 ; Gan, Shangquan 3 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr & Rural Affairs, Key Lab Anim Genet Breeding & Reprod, Beijing 100193, Peoples R China

2.Jinan Laiwu Yingtai Agr & Anim Husb Technol, Jinan 271114, Shandong, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China

关键词： Inbreeding; Selection signatures; Birth weight; Body conformation; Litter size; Sheep

期刊名称：JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY （ 影响因子：2.225； ）

ISSN： 2672-0191

年卷期： 2020 年 62 卷 6 期

页码：

收录情况： SCI

摘要： Intense artificial selection has been imposed to Luzhong mutton sheep population in the past years. Improvements on growth and reproductive performance are two breeding goals in the present herd. Although some progresses were phenotypically observed possibly due to inbreeding induced by strong selection in terms of these traits, the genomic evaluation was poorly understood. Therefore, a high-density SNP array was used to characterize the pattern of runs of homozygosity (ROH), estimate inbreeding and inbreeding depressions on early growth performance and litter size based upon ROH, and scan positive selection signatures of recent population. Consequently, a low inbreeding level was observed which had negative effects on litter size, but not on early growth performance. And 160 genes were under selection, of which some were reported to be linked to several traits of sheep including body weight, litter size, carcass and meat quality, milk yield and composition, fiber quality and health, and the top genes were associated with growth (growth hormone [GH]- growth hormone receptor [GHR]- Insulin-like growth factor 1 [IGF1] axis) and litter size (bone morphogenic proteins [BMPs]-associated). The effectiveness of previous breeding measures was highlighted, but purging selection was proposed to alleviate the inbreeding depression on litter size, providing some genomic insights to breeding management of Luzhong mutton sheep.

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