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Degradation of tetracycline antibiotics by Arthrobacter nicotianae OTC-16

文献类型： 外文期刊

作者： Shi, Yanke 1 ; Lin, Hui 2 ; Ma, Junwei 2 ; Zhu, Rongrong 1 ; Sun, Wanchun 2 ; Lin, Xiaoyan 3 ; Zhang, Jin 2 ; Zheng, Huab 1 ;

作者机构： 1.Zhejiang A&F Univ, Coll Forest & Biotechnol, Hangzhou 311300, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Environm Resources Soil & Fertilizers, Hangzhou 310021, Peoples R China

3.China Natl Rice Res Inst, Hangzhou 310006, Peoples R China

4.Zhejiang A&F Univ, State Key Lab Subtrop Silviculture, Coll Environm & Resource Sci, Hangzhou 311300, Peoples R China

关键词： Biodegradation; Oxytetracycline; Degradation pathway; Soil; Antibiotic resistant genes

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2021 年 403 卷

页码：

收录情况： SCI

摘要： Microbial degradation is an important option for combating antibiotic pollution. Arthrobacter nicotianae OTC-16 was isolated as a novel tetracycline-degrading bacterium, which could degrade oxytetracycline/tetracycline (OTC/TET). Toxicity assessment indicated that this bacterium effectively converted OTC into byproducts with less toxicity to bacterial and algal indicators. Six degradation products of OTC were tentatively identified, and a potential biotransformation pathway was proposed that includes decarbonylation, reduction, and dehydration. Bioaugmentation of TC removal with this bacterium was further studied in various matrices. In aqueous media, strain OTC-16 accelerated OTC removal over a temperature range of 20-35 degrees C, pH range of 6.0-9.0, and OTC concentration range of 25-150 mg L-1. The strain also facilitated the decrease of OTC and TET concentrations in both swine and chicken manures, with a maximum decrease of 91.54%, and increased the degradation of OTC in soils by 8.22-45.45%. A unique advantage of this bacterium in promoting OTC degradation in alkaline environments was demonstrated, where it successfully competed with the indigenous microbiota and largely decreased the relative abundances of the studied tetracycline resistance genes (tetB and tetW) in soil. This work offers a better understanding of the antibiotic bioaugmentation and new microbial sources.

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