文献类型： 外文期刊

作者： Duan, Xiao-Yan ¹ ; Guo, Kun-Yuan ³ ; Lv, Dong-Jin ⁴ ; Mei, Ren-Qiang ¹ ; Zhang, Mei-De ³ ;

作者机构： 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

3.Hubei Acad Agr Sci, Inst Chinese Herbal Med, Enshi 445000, Hubei, Peoples R China

4.Kunming Med Univ, Yunnan Canc Hosp, Dept Med Oncol, Affiliated Hosp 3, Kunming 650118, Yunnan, Peoples R China

关键词： Polyalthia simiarum; Triterpenes; Clerodane diterpenoids; Cytotoxic activities

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2020 年 147 卷

页码：

收录情况： SCI

摘要： Two new C-31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC50 value of 22.43 mu M.