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A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via GC-TOF/MS

文献类型： 外文期刊

作者： Gong, Yujie 1 ; Lyu, Wentao 2 ; Shi, Xingfen 3 ; Zou, Xiaoting 1 ; Lu, Lizhi 4 ; Yang, Hua 2 ; Xiao, Yingping 2 ;

作者机构： 1.Zhejiang Univ, Coll Anim Sci, Key Lab Mol Anim Nutr, Key Lab Anim Feed & Nutr Zhejiang Prov,Minist Edu, Hangzhou, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China

3.Zhejiang Inst Vet Drug & Feed Control, Hangzhou, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou, Peoples R China

关键词： overfeeding; fatty liver; serum metabolomic; serum enzymatic activities; serum lipid levels; Landes geese

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：4.566； 五年影响因子：4.804 ）

ISSN： 1664-042X

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： During the process of fatty liver production by overfeeding, the levels of endogenous metabolites in the serum of geese would change dramatically. This study investigated the effects of overfeeding on serum metabolism of Landes geese and the underlying mechanisms using a metabolomics approach. Sixty Landes geese of the same age were randomly divided into the following three groups with 20 replicates in each group: D0 group (free from gavage); D7 group (overfeeding for 7 days); D25 group (overfeeding for 25 days). At the end of the experiment, 10 geese of similar weight from each group were selected for slaughter and sampling. The results showed that overfeeding significantly increased the body weight and the liver weight of geese. Serum enzymatic activities and serum lipid levels were significantly enhanced following overfeeding. Gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS) was employed to explore the serum metabolic patterns, and to identify potential contributors to the formation of fatty liver and the correlated metabolic pathways. Relative to overfeeding for 7 days, a large number of endogenous molecules in serum of geese overfed for 25 days were altered. Continuous elevated levels of pyruvic acid, alanine, proline and beta-glycerophosphoric acid and reduced lactic acid level were observed in the serum of overfed geese. Pathway exploration found that the most of significantly different metabolites were involved in amino acids, carbohydrate and lipid metabolism. The present study exhibited the efficient capability of Landes geese to produce fatty liver, identified potential biomarkers and disturbed metabolic pathways in liver steatosis. These findings might reveal the underlying mechanisms of fatty liver formation and provide some theoretical basis for the diagnosis and treatment of liver diseases.

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