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miR-429-3p/LPIN1 Axis Promotes Chicken Abdominal Fat Deposition via PPAR gamma Pathway

文献类型： 外文期刊

作者： Chao, Xiaohuan 1 ; Guo, Lijin 1 ; Wang, Qi 1 ; Huang, Weiling 1 ; Liu, Manqing 1 ; Luan, Kang 1 ; Jiang, Jinqi 1 ; Lin, S 1 ;

作者机构： 1.South China Agr Univ, Guangdong Lab Lingnan Modern Agr Sci & Technol, Guangzhou, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou, Peoples R China

4.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

关键词： RNA-Seq; miR-429-3p; LPIN1 axis; preadipocyte proliferation; preadipocyte differentiation; PPARγ pathway abstract

期刊名称：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY （ 影响因子：6.684； 五年影响因子：7.219 ）

ISSN： 2296-634X

年卷期： 2020 年 8 卷

页码：

收录情况： SCI

摘要： To explore the regulatory mechanism of abdominal fat deposition in broilers, 100-day-old Sanhuang chickens (n = 12) were divided into high-fat and low-fat groups, according to the abdominal fat ratio size. Total RNA isolated from the 12 abdominal fat tissues was used for miRNA and mRNA sequencing. Results of miRNA and mRNA sequencing revealed that miR-429-3p was highly expressed in high-fat chicken whereas LPIN1 expression was downregulated. Further, we determined that miR-429-3p promoted preadipocyte proliferation and differentiation, whereas LPIN1 exerted an opposite effect. Notably, we found that the miR-429-3p/LPIN1 axis facilitated PPAR gamma pathway activation, which is closely associated with the progression of adipogenesis. In conclusion, our results provide evidence that a novel miR-429-3p/LPIN1 axis is involved in the regulation of adipogenesis, which may have a guiding role in the improvement of breeding for abdominal fat traits in broiler chickens.

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