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Combined toxicity assessment of myclobutanil and thiamethoxam to zebrafish embryos employing multi-endpoints

文献类型： 外文期刊

作者： Shen, Weifeng 1 ; Yang, Guiling 1 ; Guo, Qi 1 ; Lv, Lu 1 ; Liu, Li 1 ; Wang, Xinquan 1 ; Lou, Bao 1 ; Wang, Qiang 1 ; Wang, 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Inst Hydrobiol, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Combined toxic effect; Aquatic toxicology; Biomarker; Synergetic toxicity

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2021 年 269 卷

页码：

收录情况： SCI

摘要： It is necessary to understand the interactions between different pesticides in ecotoxicology because pesticides never appear as individual compounds but rather in combinations with other compounds. In this study, we planned to explicate the combined toxic effect of myclobutanil (MYC) and thiamethoxam (THI) on the zebrafish (Danio rerio) by adopting multiple biomarkers. Results unraveled that the 96-h LC50 values of MYC to D. rerio at various life phases ranged from 5.2 to 10.3 mg L-1, which were lower than those of THI ranging from 147 to 246 mg L-1. Combinations of MYC and THI exhibited synergetic toxicity to zebrafish embryos. The activities of antioxidative enzymes (T-SOD, Cu/Zn-SOD and POD) and detoxification enzyme (GST) were obviously varied in most of the MYC, THI and combined exposures compared to the control. The mRNA expressions of eight genes (Cu-sod, cas3, it-8, cxcl, er alpha, crh, cyp17 and diol) involved in antioxidation, apoptosis, immunity and endocrine were obviously altered in the combined exposure of MYC and THI compared to their individual exposures. Our findings hinted the threats when YMC and THI co-existed, which would be beneficial for the risk assessments of pesticide mixtures. (C) 2020 Elsevier Ltd. All rights reserved.

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