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Development and validation of modified QuEChERS method combined with LC-MS/MS for high-throughput analysis of per- and polyfluoroalkyl substances in fish samples

文献类型： 外文期刊

作者： Liu, Xiaoqi 1 ; Liu, Zhenzhen 2 ; Zhao, Huiyu 2 ; Shi, Ranran 1 ; Wang, Jiao 2 ; Liu, Juanjuan 1 ; Di, Shanshan 2 ; Wang, Zhiwei 2 ; Wang, Xinquan 1 ; Liu, Lianliang 2 ; Qi, Peipei 4 ;

作者机构： 1.Ningbo Univ, State Key Lab Managing Biot & Chem Threats Qual &, Ningbo 315832, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

3.169 Qixing South Rd, Ningbo 315832, Peoples R China

4.198 Shiqiao Rd, Hangzhou 310021, Peoples R China

关键词： PFAS; Integrated QuEChERS; Liquid chromatography -tandem mass; spectrometry; Liquid chromatography-tandem mass; Fe3O4-TiO2

期刊名称：MICROCHEMICAL JOURNAL （ 影响因子：4.8； 五年影响因子：4.5 ）

ISSN： 0026-265X

年卷期： 2024 年 199 卷

页码：

收录情况： SCI

摘要： A rapid and accurate integrated QuEChERS method was developed for analyzing 26 of per- and polyfluoroalkyl substances (PFAS) in fish samples. The magnetic Fe3O4-TiO2 material was used as magnetic separation medium and purification adsorbent to remove proteins. This facilitated rapid phase separation and enabled the extraction and purification processes to be completed in a single step within 5 min. Key factors of the integrated QuEChERS method, including the extraction solution, salting-out and dehydrating reagents, and purification adsorbents, were optimized to ensure effective recovery of PFAS and the elimination of matrix interferences. Under these optimized conditions, systematic method validation exhibited good linearity (R-2 > 0.9931). The method limit of detection ranged from 0.010 to 0.048 mu g/kg, and the method limit of quantitation ranged from 0.025 to 0.050 mu g/kg. The PFAS recoveries varied from 71.3 % to 116.3 % at spiked concentrations of 0.025, 0.05, 10 and 100 mu g/kg, with intra-day RSDs and inter-day RSDs below 11.8 % and 9.0 %, respectively. Compared to the reported QuEChERS and SPE methods, the integrated QuEChERS approach presents distinct advantages in operating procedure, organic solvent usage, pre-treatment time, and offers comparable recoveries and RSDs. When this method was applied to real sample analyses, PFAS were detected in all fish samples with total concentrations ranging from 0.813 mu g/kg to 4.015 mu g/kg. Consequently, the developed method showcases its significant value for the rapid and high-throughput analysis of multiple PFAS in diverse fish samples.

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