Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro
文献类型： 外文期刊
作者： Shen, Qingshan 1 ; Zhang, Chunhui 1 ; Mo, Haizhen 3 ; Zhang, Hongru 1 ; Qin, Xiaojie 1 ; Li, Juan 1 ; Zhang, Zhiqiang; 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Key Lab Agroprod Proc, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China
2.Univ Liege, Lab Biomass & Green Technol, Gembloux Agrobio Tech, Passage Deportes 2, B-5030 Gembloux, Belgium
3.Shaanxi Univ Sci & Technol, Sch Food & Biol Engn, Xian 710021, Peoples R China
4.Shandong Haiyu Biotechnol Co Ltd, Jining 272113, Peoples R China
关键词： Chondroitin sulfate; Calcium; Chondrocyte; Proliferation; Bone care
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）
ISSN： 0144-8617
年卷期： 2021 年 254 卷
页码：
收录情况： SCI
摘要： Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-beta 1 secretion induced by CSCa could activate the TGF-beta/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements.
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