Carbendazim exposure during the larval stage suppresses major royal jelly protein expression in nurse bees (Apis mellifera)
文献类型： 外文期刊
作者： Wang, Kang 1 ; Chen, Heng 1 ; Lin, Zhe-Guang 1 ; Niu, Qing-Sheng 2 ; Wang, Zhi 2 ; Gao, Fu-Chao 3 ; Ji, Ting 1 ;
作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Jiangsu, Peoples R China
2.Jilin Prov Inst Apicultural Sci, Key Lab Bee Genet & Breeding, Jilin 132108, Jilin, Peoples R China
3.Heilongjiang Acad Agr Sci, Mudanjiang Branch, Harbin 153000, Heilongjiang, Peoples R China
关键词： Apis mellifera; carbendazim; Proteomics; Major royal jelly protein; Sublethal dose effect; Field concentration
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2021 年 266 卷
页码：
收录情况： SCI
摘要： Studying the sublethal effects of agrochemical pesticides on nontarget honeybees (Apis mellifera) is important for agricultural development. Carbendazim is a widely used broad-spectrum fungicide that inhibits mitotic microtubule formation and cell division. However, the impact of carbendazim on bee health and development has not been fully elucidated. Here, using proteomics approaches, we assessed in vitro the changes in the expression of functional proteins in the head of newly emerged adults following treatment with field concentration of carbendazim during the larval stage. Treatment with carbendazim severely altered 266 protein expression patterns in the heads of adults and 218 of them showed downregulation after carbendazim exposure. Notably, major royal jelly proteins, a crucial multifunctional protein family with irreplaceable function in sustaining the development of colonies, were significantly suppressed in carbendazim-treated bees. This result was verified in both head and hypopharyngeal gland of nurse bees. Moreover, visual and olfactory loss, immune functions, muscular activity, social behavior, neural and brain development, protein synthesis and modification, and metabolism-related proteins were likely inhibited by carbendazim treatment. Together, these results suggest that carbendazim is an environmental risk factor that likely weakens bee colonies, partially due to reduced expression of major royal jelly proteins, which may be potential causes of colony collapse disorder. (C) 2020 Elsevier Ltd. All rights reserved.
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