Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats
文献类型： 外文期刊
作者： Li, Zhao-Rong 1 ; Jia, Rui-Bo 1 ; Wu, Juan 1 ; Lin, Lianzhu 1 ; Ou, Zhi-Rong 1 ; Liao, Bingwu 1 ; Zhang, Lixia 2 ; Zhang, 1 ;
作者机构： 1.South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China
2.Henan Acad Agr Sci, Inst Agr Prod Proc, 116 Huayuan Rd, Zhengzhou 450002, Peoples R China
3.Guangdong Food Green Proc & Nutr Regulat Technol, Guangzhou 510640, Peoples R China
关键词： Sargassum fusiforme polysaccharide; Acarbose; Auxiliary anti-diabetic effects
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 2020影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2021 年 170 卷
收录情况： SCI
摘要： The objective of present research was to explore whether Sargassum fusiforme polysaccharide (SFP) could partly replace acarbose against type 2 diabetes in rats. Results indicated that SFP co-administered with low-dose acarbose intervention typically mitigated diabetic symptoms and serum profiles and exhibited better antidiabetic effects than single acarbose treatment in controlling fasting blood glucose, improving insulin resistance and mitigating kidney injuries. The RT-qPCR analysis indicated that SFP co-administered with low-dose acarbose administration distinctly activated the IRS/PI3K/AKT signaling pathway compared with single acarbose treatment. Moreover, the co-administration also restrained liver fat accumulation via affecting the expression of HMGCR and SREBP-1c genes. In addition, the 165 rRNA gene sequencing analysis indicated that SFP co-administered with low-dose acarbose significantly restored beneficial composition of gut flora in diabetic rats, such as the increase of Muribaculaceae, Lachnospiraceae, Bifidobacterium, Ruminococcaceae_UCG-014, Ruminococcus_1, Romboutsia, Eggerthellaceae, Alistipes and Faecalibaculum, and the decrease of Escherichia-Shigella. These results suggested that SFP, the novel natural adjuvant of acarbose, displayed the desirable benefits in minimizing the dose of drug, while improving the anti-diabetic efficiency. (C) 2020 Elsevier B.V. All rights reserved.
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