Marine Alkaloid Pityriacitrin and Its Analogues: Discovery, Structures, Synthetic Methods and Biological Properties
文献类型： 外文期刊
作者： Ke, Shaoyong 1 ; Xu, Tingting 1 ; Min, Yong 1 ; Wan, Zhongyi 1 ; Yang, Ziwen 1 ; Wang, Kaimei 1 ;
作者机构： 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
关键词： Marine alkaloid; pityriacitrin; analogues; structure; synthesis; biological properties
期刊名称：MINI-REVIEWS IN MEDICINAL CHEMISTRY （ 影响因子：3.862； 五年影响因子：3.742 ）
ISSN： 1389-5575
年卷期： 2021 年 21 卷 2 期
页码：
收录情况： SCI
摘要： Pityriacitrin is a natural marine alkaloid with a typical beta-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. The special structural features for pityriacitrin lead to the increasing research interest and the emergence of versatile derivatives, and many pityriacitrin analogues have been isolated or synthesized over the past decades. The structural diversity and evolved biological activity of these natural alkaloids can offer opportunities for the development of highly potential novel drugs with a new mechanism of action, and therefore, the aim of this brief review is to describe the discovery, synthesis, and biological properties of natural pityriacitrin and its derivatives, as well as the isolation source.
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