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C-type lectin 5, a novel pattern recognition receptor for the JAK/STAT signaling pathway in Bombyx mori

文献类型： 外文期刊

作者： Geng, Tao 1 ; Lu, Fuping 1 ; Wu, Huazhou 1 ; Wang, Yongsong 2 ; Lou, Dezhao 3 ; Tu, Nana 4 ; Zhu, Feng 5 ; Wang, Shuchang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Environm & Plant Protect, Haikou 571101, Hainan, Peoples R China

2.Hainan Univ, Coll Forestry, Haikou 570228, Hainan, Peoples R China

3.Hainan Univ, Coll Plant Protect, Haikou 570228, Hainan, Peoples R China

4.Hainan Univ, Coll Trop Crop, Haikou 570228, Hainan, Peoples R China

5.Zaozhuang Univ, Coll Life Sci, Zaozhuang 277160, Peoples R China

关键词： JAK/STAT signaling pathway; C-type lectin 5; Pattern recognition receptors; Bombyx mori; Beauveria bassiana

期刊名称：JOURNAL OF INVERTEBRATE PATHOLOGY （ 影响因子：2.841； 五年影响因子：3.368 ）

ISSN： 0022-2011

年卷期： 2021 年 179 卷

页码：

收录情况： SCI

摘要： The Janus kinase/signal transducer and activator of transcription cascade transduction (JAK/STAT) signaling pathway is highly conserved in mammals, but the pattern recognition receptors (PRRs) and their functions are unclear. We found that the expression pattern of Bombyx mori C-type lectin 5 (BmCTL 5) had a synergy relevance with the JAK/STAT signaling pathway against Beauveria bassiana. An RNAi assay, subcellular localization analysis, yeast two-hybrid technique, protein recruitment experiment and pathogen infection tests were used to explore the roles of BmCTL 5 in the JAK/STAT signaling pathway. Knock-down of the BmCTL 5 suppressed the JAK/STAT signaling pathway and the PO cascade of nodule melanization. BmCTL 5 is located in the cytomembrane and interacted with BmHOP both in yeast and B. mori ovary cells N (BmN cells). BmCTL 5 and the JAK/STAT signaling pathway was activated by B. bassiana but only slightly activated by B. mori cytoplasmic polyhedrosis virus (BmCPV), Nosema bombycis and bacteria LP S. These findings suggest that BmCTL 5 might be an important PRR for the JAK/STAT signaling pathway and may mediate the nodule melanization for fungi infection. These data provide insights into the immune mechanism of the JAK/STAT signaling pathway in insects and aid understanding of the mechanism of the JAK/STAT signaling pathway and adaptive immune systems in mammals.

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