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Identifying new compounds with potential pharmaceutical and physiological activity in Areca catechu and Areca triandra via a non-targeted metabolomic approach

文献类型： 外文期刊

作者： Wu, Jiao 1 ; Cui, Chuang 1 ; Zhang, He 1 ; Liu, Dongjun 1 ; Schreiber, Lukas 3 ; Qin, Weiquan 4 ; Wan, Yinglang 1 ;

作者机构： 1.Hainan Univ, Coll Trop Crops, Hainan Key Lab Sustainable Utilizat Trop Bioresou, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571737, Hainan, Peoples R China

3.Univ Bonn, Inst Cellular & Mol Bot, D-53115 Bonn, Germany

4.Chinese Acad Trop Agr Sci, Coconut Res Inst, Wenchang 571339, Hainan, Peoples R China

5.Huachuang Inst Areca Res Hainan, Haikou 570228, Hainan, Peoples R China

关键词： Areca catechu; Areca triandra; metabolomics; traditional medicine; UPLC-MS/MS

期刊名称：PHYTOCHEMICAL ANALYSIS （ 影响因子：3.373； 五年影响因子：2.959 ）

ISSN： 0958-0344

年卷期：

页码：

收录情况： SCI

摘要： Introduction: The fruits of Areca catechu, also called areca nuts, are widely used as popular masticatory and traditional herbal medicine in Asia. Besides arecoline and related alkaloids, limited information is available about further primary and secondary metabolites and their potential biological activities. Objective: Here we aimed to further enhance our knowledge on phytochemical profiles of A. catechu and Areca triandra fruits. We intended to comprehensively identify metabolites in A. catechu and A. triandra fruits. Methodology: Metabolites were identified by ultra-performance liquid chromatography triple-quadrupole tandem mass spectrometry (UPLC-MS/MS). The occurrence of 12 selected bioactive compounds in 4 different developmental stages of A. catechu and A. triandra was quantified by LC-MS/MS. Results: A total of 791 metabolites was identified. Of these, 115 metabolites could successfully be mapped to 44 Kyoto Encyclopedia of Genes and Genomes metabolic pathways, and 154 metabolites occurred at significantly different levels in A. catechu compared to A. triandra. Several components with known biological activities were identified for the first time in A. catechu and A. triandra. The abundance of many of these new components was similar in A. catechu and A. triandra, but significantly different between the pericarp and the seeds of A. catechu fruits. Conclusions: Metabolic profiles indicate that fruits of the Areca species compared here have similar primary and secondary metabolites. Our findings provide new insights into A. catechu and A. triandra as valuable sources for traditional medicine and they pave the way for further studies to potentially improve the underlying pharmaceutical and physiological effects.

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